2021
Lipidomic Profiles of Plasma Exosomes Identify Candidate Biomarkers for Early Detection of Hepatocellular Carcinoma in Patients with Cirrhosis
Sanchez J, Jiao J, Kwan S, Veillon L, Warmoes M, Tan L, Odewole M, Rich N, Wei P, Lorenzi P, Singal A, Beretta L. Lipidomic Profiles of Plasma Exosomes Identify Candidate Biomarkers for Early Detection of Hepatocellular Carcinoma in Patients with Cirrhosis. Cancer Prevention Research 2021, 14: canprevres.0612.2021. PMID: 34253566, PMCID: PMC8546639, DOI: 10.1158/1940-6207.capr-20-0612.Peer-Reviewed Original ResearchConceptsLogistic regression analysisHCC exosomesCirrhotic patientsEarly detectionHepatocellular carcinomaCandidate biomarkersTumor developmentNoninvasive diagnostic biomarkersRegression analysisHCC surveillanceLipid profileEndocannabinoid signalingHCC diagnosisNovel biomarkersLipid classesDiagnostic biomarkersPlasma exosomesLipidomic profilesGlycerophospholipid metabolismHCCPatientsBiomarkersUntargeted lipidomicsCarcinomaDifferential effects
2015
miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells
Zhang J, Jiao J, Cermelli S, Muir K, Jung K, Zou R, Rashid A, Gagea M, Zabludoff S, Kalluri R, Beretta L. miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells. Cancer Research 2015, 75: 1859-1867. PMID: 25769721, PMCID: PMC4603420, DOI: 10.1158/0008-5472.can-14-1254.Peer-Reviewed Original ResearchConceptsCancer-associated stromal cellsLiver fibrosisMiR-21Liver cancerProgenitor cellsStromal cellsTumor developmentAssociated liver fibrosisPrevents tumor developmentLiver tumor growthLiver progenitor cellsPreclinical evidenceIntrahepatic cholangiocarcinomaPoor prognosisChemopreventive targetHepatocellular carcinomaHepatic deletionNotch2 inhibitionTumor growthMalignant developmentFibrosisInducing ApoptosisIntegrin αvCancerCell survival