2021
Lipidomic Profiles of Plasma Exosomes Identify Candidate Biomarkers for Early Detection of Hepatocellular Carcinoma in Patients with Cirrhosis
Sanchez J, Jiao J, Kwan S, Veillon L, Warmoes M, Tan L, Odewole M, Rich N, Wei P, Lorenzi P, Singal A, Beretta L. Lipidomic Profiles of Plasma Exosomes Identify Candidate Biomarkers for Early Detection of Hepatocellular Carcinoma in Patients with Cirrhosis. Cancer Prevention Research 2021, 14: canprevres.0612.2021. PMID: 34253566, PMCID: PMC8546639, DOI: 10.1158/1940-6207.capr-20-0612.Peer-Reviewed Original ResearchConceptsLogistic regression analysisHCC exosomesCirrhotic patientsEarly detectionHepatocellular carcinomaCandidate biomarkersTumor developmentNoninvasive diagnostic biomarkersRegression analysisHCC surveillanceLipid profileEndocannabinoid signalingHCC diagnosisNovel biomarkersLipid classesDiagnostic biomarkersPlasma exosomesLipidomic profilesGlycerophospholipid metabolismHCCPatientsBiomarkersUntargeted lipidomicsCarcinomaDifferential effectsSomatic Mutations in Circulating Cell-Free DNA and Risk for Hepatocellular Carcinoma in Hispanics
Jiao J, Sanchez J, Thompson E, Mao X, McCormick J, Fisher-Hoch S, Futreal P, Zhang J, Beretta L. Somatic Mutations in Circulating Cell-Free DNA and Risk for Hepatocellular Carcinoma in Hispanics. International Journal Of Molecular Sciences 2021, 22: 7411. PMID: 34299031, PMCID: PMC8304329, DOI: 10.3390/ijms22147411.Peer-Reviewed Original ResearchConceptsAdvanced liver fibrosisCell-free DNAHigher cfDNA concentrationsHepatocellular carcinomaLiver fibrosisCfDNA concentrationHCC patientsOverall survivalAdvanced fibrosisHCC risk predictionShorter overall survivalMajor risk factorNon-invasive markerPlasma cell-free DNADetectable mutationsSomatic mutationsCirculating Cell-Free DNARisk factorsHCC developmentCancer-associated genesDeath outcomesFibrosisPatientsNonsynonymous mutationsRisk predictionCirculating Fatty Acids Associated with Advanced Liver Fibrosis and Hepatocellular Carcinoma in South Texas Hispanics
Jiao J, Kwan S, Sabotta C, Tanaka H, Veillon L, Warmoes M, Lorenzi P, Wang Y, Wei P, Hawk E, Almeda J, McCormick J, Fisher-Hoch S, Beretta L. Circulating Fatty Acids Associated with Advanced Liver Fibrosis and Hepatocellular Carcinoma in South Texas Hispanics. Cancer Epidemiology Biomarkers & Prevention 2021, 30: 1643-1651. PMID: 34155064, PMCID: PMC8419070, DOI: 10.1158/1055-9965.epi-21-0183.Peer-Reviewed Original ResearchConceptsAdvanced liver fibrosisNonalcoholic fatty liver diseaseLiver fibrosisHepatocellular carcinomaFree fatty acidsVLC nPlasma concentrationsCameron County Hispanic CohortFatty liver diseaseLiver fibrosis progressionRelatives of patientsStrong predictive factorLow plasma concentrationsSecond-degree relativesLiver fibrosis severityOdd-chain SFAsTexas HispanicsVLC-SFAFIB-4Advanced fibrosisLiver diseaseNAFLD progressionFibrosis progressionN3-PUFAsFatty acids
2020
Bile Acid Changes Associated With Liver Fibrosis and Steatosis in the Mexican‐American Population of South Texas
Kwan S, Jiao J, Qi J, Wang Y, Wei P, McCormick J, Fisher‐Hoch S, Beretta L. Bile Acid Changes Associated With Liver Fibrosis and Steatosis in the Mexican‐American Population of South Texas. Hepatology Communications 2020, 4: 555-568. PMID: 32258950, PMCID: PMC7109342, DOI: 10.1002/hep4.1490.Peer-Reviewed Original ResearchBile acid changesBile acid levelsNonalcoholic fatty liver diseaseFatty liver diseaseBile acid profilesLiver fibrosisLiver diseaseBile acidsAcid levelsHepatocellular carcinomaHigh-risk Mexican-American populationPrimary conjugated bile acidsUnconjugated secondary bile acidsTotal bile acid levelsCameron County Hispanic CohortGut microbiome contributesLithocholic acid levelsSignificant liver fibrosisSecondary bile acidsCommon risk factorsIndividual bile acidsEarly preventive interventionsConjugated bile acidsAcid changesAdvanced fibrosis
2018
Toll-like receptor 4: a target for chemoprevention of hepatocellular carcinoma in obesity and steatohepatitis
Nguyen J, Jiao J, Smoot K, Watt G, Zhao C, Song X, Stevenson H, McCormick J, Fisher-Hoch S, Zhang J, Futreal P, Beretta L. Toll-like receptor 4: a target for chemoprevention of hepatocellular carcinoma in obesity and steatohepatitis. Oncotarget 2018, 9: 29495-29507. PMID: 30034633, PMCID: PMC6047684, DOI: 10.18632/oncotarget.25685.Peer-Reviewed Original ResearchNon-alcoholic fatty liver diseaseTLR4 mRNA expressionHepatocellular carcinomaMRNA expressionIL-6HCC patientsHCC developmentHCC tumorsIL-10 mRNA expressionToll-like receptor 4Fatty liver diseaseWhole-exome sequencingIngenuity Pathway AnalysisDistant liverIL-10Liver diseaseTLR4 inhibitorProinflammatory responseReceptor 4TLR4 activationHCC chemopreventionChemopreventionKey mediatorTumorsMiceTelomerase reverse transcriptase mutations in plasma DNA in patients with hepatocellular carcinoma or cirrhosis: Prevalence and risk factors
Jiao J, Watt G, Stevenson H, Calderone T, Fisher‐Hoch S, Ye Y, Wu X, Vierling J, Beretta L. Telomerase reverse transcriptase mutations in plasma DNA in patients with hepatocellular carcinoma or cirrhosis: Prevalence and risk factors. Hepatology Communications 2018, 2: 718-731. PMID: 29881823, PMCID: PMC5983165, DOI: 10.1002/hep4.1187.Peer-Reviewed Original ResearchEvidence of HCCHepatitis C virusReverse transcriptase mutationsCell-free DNAHepatocellular carcinomaMale patientsTranscriptase mutationsLong-term imaging surveillancePlasma cell-free DNAFrequent genetic alterationsAlcoholic cirrhosisCancer Genome AtlasImaging surveillanceT promoter mutationClinical parametersMale sexPoor prognosisC virusRisk factorsSimilar prevalenceEarly biomarkersFamily historyHigh prevalenceCirrhosisPatientsDepletion of S100A4+ stromal cells does not prevent HCC development but reduces the stem cell-like phenotype of the tumors
Jiao J, González Á, Stevenson H, Gagea M, Sugimoto H, Kalluri R, Beretta L. Depletion of S100A4+ stromal cells does not prevent HCC development but reduces the stem cell-like phenotype of the tumors. Experimental & Molecular Medicine 2018, 50: e422-e422. PMID: 29303514, PMCID: PMC5992984, DOI: 10.1038/emm.2017.175.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinoma, HepatocellularCell DifferentiationGene Expression Regulation, NeoplasticHepatitisHepatocytesLiver NeoplasmsLiver Neoplasms, ExperimentalMice, KnockoutMice, TransgenicNeoplastic Stem CellsNon-alcoholic Fatty Liver DiseasePTEN PhosphohydrolaseS100 Calcium-Binding Protein A4Stromal CellsConceptsDepletion of S100A4Hepatocellular carcinomaMouse modelCalcium-binding protein S100A4Stromal cellsStemness phenotypeDevelopment of HCCOval cell hyperplasiaReduction of inflammationStemness propertiesCell stemness propertiesNew mouse modelStem cell-like phenotypeViral thymidine kinaseCell-like phenotypeLiver diseaseCell hyperplasiaPoor prognosisGanciclovir injectionsNAS scoreAdjacent liverGastric cancerHCC developmentProtein S100A4Hepatic deletion
2017
Prevalence of Aflatoxin-associated TP53R249S mutation in Hepatocellular Carcinoma in Hispanics in South Texas
Jiao J, Niu W, Wang Y, Baggerly K, Ye Y, Wu X, Davenport D, Almeda J, Betancourt-Garcia M, Forse R, Stevenson H, Watt G, McCormick J, Fisher-Hoch S, Beretta L. Prevalence of Aflatoxin-associated TP53R249S mutation in Hepatocellular Carcinoma in Hispanics in South Texas. Cancer Prevention Research 2017, 11: 103-112. PMID: 29089331, PMCID: PMC5811406, DOI: 10.1158/1940-6207.capr-17-0235.Peer-Reviewed Original ResearchConceptsAdvanced fibrosisHepatocellular carcinomaCell-free DNAHCC patientsHispanic subjectsShorter overall survivalPlasma cell-free DNAAsian HCC patientsOverall survivalWorse prognosisAflatoxin exposureHigh incidenceCirrhosisHCC tumorsPromising biomarkerDietary exposureFibrosisYounger agePatientsDroplet digital PCRHispanicsSomatic mutationsFamily membersUpstream regulatorSubjects
2015
miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells
Zhang J, Jiao J, Cermelli S, Muir K, Jung K, Zou R, Rashid A, Gagea M, Zabludoff S, Kalluri R, Beretta L. miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells. Cancer Research 2015, 75: 1859-1867. PMID: 25769721, PMCID: PMC4603420, DOI: 10.1158/0008-5472.can-14-1254.Peer-Reviewed Original ResearchConceptsCancer-associated stromal cellsLiver fibrosisMiR-21Liver cancerProgenitor cellsStromal cellsTumor developmentAssociated liver fibrosisPrevents tumor developmentLiver tumor growthLiver progenitor cellsPreclinical evidenceIntrahepatic cholangiocarcinomaPoor prognosisChemopreventive targetHepatocellular carcinomaHepatic deletionNotch2 inhibitionTumor growthMalignant developmentFibrosisInducing ApoptosisIntegrin αvCancerCell survival