Somatic Mutations in Circulating Cell-Free DNA and Risk for Hepatocellular Carcinoma in Hispanics
Jiao J, Sanchez J, Thompson E, Mao X, McCormick J, Fisher-Hoch S, Futreal P, Zhang J, Beretta L. Somatic Mutations in Circulating Cell-Free DNA and Risk for Hepatocellular Carcinoma in Hispanics. International Journal Of Molecular Sciences 2021, 22: 7411. PMID: 34299031, PMCID: PMC8304329, DOI: 10.3390/ijms22147411.Peer-Reviewed Original ResearchConceptsAdvanced liver fibrosisCell-free DNAHigher cfDNA concentrationsHepatocellular carcinomaLiver fibrosisCfDNA concentrationHCC patientsOverall survivalAdvanced fibrosisHCC risk predictionShorter overall survivalMajor risk factorNon-invasive markerPlasma cell-free DNADetectable mutationsSomatic mutationsCirculating Cell-Free DNARisk factorsHCC developmentCancer-associated genesDeath outcomesFibrosisPatientsNonsynonymous mutationsRisk predictionCirculating Fatty Acids Associated with Advanced Liver Fibrosis and Hepatocellular Carcinoma in South Texas Hispanics
Jiao J, Kwan S, Sabotta C, Tanaka H, Veillon L, Warmoes M, Lorenzi P, Wang Y, Wei P, Hawk E, Almeda J, McCormick J, Fisher-Hoch S, Beretta L. Circulating Fatty Acids Associated with Advanced Liver Fibrosis and Hepatocellular Carcinoma in South Texas Hispanics. Cancer Epidemiology Biomarkers & Prevention 2021, 30: 1643-1651. PMID: 34155064, PMCID: PMC8419070, DOI: 10.1158/1055-9965.epi-21-0183.Peer-Reviewed Original ResearchConceptsAdvanced liver fibrosisNonalcoholic fatty liver diseaseLiver fibrosisHepatocellular carcinomaFree fatty acidsVLC nPlasma concentrationsCameron County Hispanic CohortFatty liver diseaseLiver fibrosis progressionRelatives of patientsStrong predictive factorLow plasma concentrationsSecond-degree relativesLiver fibrosis severityOdd-chain SFAsTexas HispanicsVLC-SFAFIB-4Advanced fibrosisLiver diseaseNAFLD progressionFibrosis progressionN3-PUFAsFatty acids