Identification and mechanistic basis of non-ACE2 blocking neutralizing antibodies from COVID-19 patients with deep RNA sequencing and molecular dynamics simulations
Fredericks A, East K, Shi Y, Liu J, Maschietto F, Ayala A, Cioffi W, Cohen M, Fairbrother W, Lefort C, Nau G, Levy M, Wang J, Batista V, Lisi G, Monaghan S. Identification and mechanistic basis of non-ACE2 blocking neutralizing antibodies from COVID-19 patients with deep RNA sequencing and molecular dynamics simulations. Frontiers In Molecular Biosciences 2022, 9: 1080964. PMID: 36589229, PMCID: PMC9800910, DOI: 10.3389/fmolb.2022.1080964.Peer-Reviewed Original ResearchCOVID-19 patientsSARS-CoV-2Severe acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Spike proteinSevere COVID-19Intensive care unitSyndrome coronavirus 2RNA sequencingCertain immune responsesCOVID-19 infectionSARS-CoV-2 spike proteinEffectiveness of treatmentDeep RNA sequencingICU admissionCare unitSingle centerCoronavirus 2Peripheral bloodMultiple time pointsClinical dataImmune responseEarly infection timesSpecific NAbs