2008
Mechanism of Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase by a Stavudine Analogue, 4′-Ethynyl Stavudine Triphosphate
Yang G, Wang J, Cheng Y, Dutschman GE, Tanaka H, Baba M, Cheng YC. Mechanism of Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase by a Stavudine Analogue, 4′-Ethynyl Stavudine Triphosphate. Antimicrobial Agents And Chemotherapy 2008, 52: 2035-2042. PMID: 18391035, PMCID: PMC2415781, DOI: 10.1128/aac.00083-08.Peer-Reviewed Original ResearchConceptsM184V mutantNucleoside reverse transcriptase inhibitorHuman immunodeficiency virus type 1Immunodeficiency virus type 1Human immunodeficiency virus type 1 reverse transcriptaseReverse transcriptase inhibitorType 1 reverse transcriptaseVirus type 1Mechanism of inhibitionHIV-1 RTWild-type RTStavudine triphosphateTranscriptase inhibitorD4TD4TTPType 1WT RTMutant RTsReverse transcriptase
1994
Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1.
Smerdon S, Jäger J, Wang J, Kohlstaedt L, Chirino A, Friedman J, Rice P, Steitz T. Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 3911-3915. PMID: 7513427, PMCID: PMC43692, DOI: 10.1073/pnas.91.9.3911.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAntiviral AgentsBinding SitesCrystallography, X-RayDrug Resistance, MicrobialHIV Reverse TranscriptaseHIV-1Models, MolecularMolecular Sequence DataMolecular StructureNevirapineNucleosidesProtein Structure, TertiaryPyridinesReverse Transcriptase InhibitorsRNA-Directed DNA PolymeraseConceptsHuman immunodeficiency virus type 1Immunodeficiency virus type 1Drug resistance mutationsVirus type 1Type 1Reverse transcriptaseHIV-1 reverse transcriptaseNevirapineResistance mutationsNonnucleoside inhibitorsDrugsViable virusSpecific inhibitorInhibitorsClose contactMutationsTranscriptaseSame binding site