2024
Mutation-induced shift of the photosystem II active site reveals insight into conserved water channels
Flesher D, Liu J, Wang J, Gisriel C, Yang K, Batista V, Debus R, Brudvig G. Mutation-induced shift of the photosystem II active site reveals insight into conserved water channels. Journal Of Biological Chemistry 2024, 300: 107475. PMID: 38879008, PMCID: PMC11294709, DOI: 10.1016/j.jbc.2024.107475.Peer-Reviewed Original ResearchOxygen-evolving complexPhotosystem II active sitePhotosystem IIJahn-Teller distortionPhotosystem II complexD1-Asp170Jahn-TellerResolution cryo-EM structureMutation-induced structural changesCryo-EM structureMagnetic propertiesD1 subunitActive siteOxygenic photosynthesisMutagenesis studiesLight-driven water oxidationSpectroscopic propertiesStructural basisSpectroscopic dataAmino acidsWater oxidation mechanismPhotosystemMutationsMutation-induced shiftWater oxidation
2004
Visualizing a Circadian Clock Protein Crystal Structure of KaiC and Functional Insights
Pattanayek R, Wang J, Mori T, Xu Y, Johnson CH, Egli M. Visualizing a Circadian Clock Protein Crystal Structure of KaiC and Functional Insights. Molecular Cell 2004, 15: 375-388. PMID: 15304218, DOI: 10.1016/j.molcel.2004.07.013.Peer-Reviewed Original ResearchConceptsClock protein complexesAuto-phosphorylation siteGlobal gene expressionCircadian biological clockHomohexameric complexEvolutionary relationshipsProtein complexesCircadian clockworkATP bindingFunctional insightsCircadian proteinsKaiCProtein crystal structuresCentral poreGene expressionMolecular componentsBiochemical mechanismsBiological clockCrystal structureDouble donutComplex formationProteinCircadian rhythmicityMutationsCyanobacteria
1994
Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1.
Smerdon S, Jäger J, Wang J, Kohlstaedt L, Chirino A, Friedman J, Rice P, Steitz T. Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 3911-3915. PMID: 7513427, PMCID: PMC43692, DOI: 10.1073/pnas.91.9.3911.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAntiviral AgentsBinding SitesCrystallography, X-RayDrug Resistance, MicrobialHIV Reverse TranscriptaseHIV-1Models, MolecularMolecular Sequence DataMolecular StructureNevirapineNucleosidesProtein Structure, TertiaryPyridinesReverse Transcriptase InhibitorsRNA-Directed DNA PolymeraseConceptsHuman immunodeficiency virus type 1Immunodeficiency virus type 1Drug resistance mutationsVirus type 1Type 1Reverse transcriptaseHIV-1 reverse transcriptaseNevirapineResistance mutationsNonnucleoside inhibitorsDrugsViable virusSpecific inhibitorInhibitorsClose contactMutationsTranscriptaseSame binding site