Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1.
Smerdon S, Jäger J, Wang J, Kohlstaedt L, Chirino A, Friedman J, Rice P, Steitz T. Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 3911-3915. PMID: 7513427, PMCID: PMC43692, DOI: 10.1073/pnas.91.9.3911.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAntiviral AgentsBinding SitesCrystallography, X-RayDrug Resistance, MicrobialHIV Reverse TranscriptaseHIV-1Models, MolecularMolecular Sequence DataMolecular StructureNevirapineNucleosidesProtein Structure, TertiaryPyridinesReverse Transcriptase InhibitorsRNA-Directed DNA PolymeraseConceptsHuman immunodeficiency virus type 1Immunodeficiency virus type 1Drug resistance mutationsVirus type 1Type 1Reverse transcriptaseHIV-1 reverse transcriptaseNevirapineResistance mutationsNonnucleoside inhibitorsDrugsViable virusSpecific inhibitorInhibitorsClose contactMutationsTranscriptaseSame binding site