Antisense to the Epstein‐Barr virus (EBV)‐encoded latent membrane protein 1 (LMP‐1) sensitizes EBV‐immortalized B cells to transforming growth factor‐beta and chemotherapeutic agents
Kenney J, Guinness M, Reiss M, Lacy J. Antisense to the Epstein‐Barr virus (EBV)‐encoded latent membrane protein 1 (LMP‐1) sensitizes EBV‐immortalized B cells to transforming growth factor‐beta and chemotherapeutic agents. International Journal Of Cancer 2000, 91: 89-98. PMID: 11149426, DOI: 10.1002/1097-0215(20010101)91:1<89::aid-ijc1015>3.0.co;2-u.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Agents, HormonalAntineoplastic Agents, PhytogenicApoptosisB-LymphocytesCell DivisionCell Line, TransformedCell SeparationCyclin D2CyclinsDexamethasoneDNA, AntisenseDown-RegulationEtoposideFlow CytometryHumansImmunoblottingLymphomaMyeloid Cell Leukemia Sequence 1 ProteinNeoplasm ProteinsProto-Oncogene Proteins c-bcl-2Transforming Growth Factor betaTumor Cells, CulturedVincristineViral Matrix ProteinsConceptsLatent membrane protein 1Epstein-Barr virusLymphoblastoid cell linesLMP-1B cellsMembrane protein 1Antisense oligodeoxynucleotidesEBV-positive lymphoproliferative disordersChemotherapeutic agentsEBV-positive lymphoblastoid cell linesEBV-positive cell linesProtein 1Human B cell growthAntisense treatmentApoptotic effectsRational therapeutic targetShort-term treatmentLMP-1 expressionRational therapeutic strategiesB cell growthCell linesLMP-1 proteinTumor necrosis factor receptor familyInhibition of proliferationLymphoproliferative disorders