1992
Transcriptional regulation of the human IgE receptor (Fc epsilon RII/CD23) by EBV. Identification of EBV-responsive regulatory elements in intron 1.
Lacy J, Rudnick H. Transcriptional regulation of the human IgE receptor (Fc epsilon RII/CD23) by EBV. Identification of EBV-responsive regulatory elements in intron 1. The Journal Of Immunology 1992, 148: 1554-60. PMID: 1311350, DOI: 10.4049/jimmunol.148.5.1554.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, Differentiation, B-LymphocyteAntigens, ViralBase SequenceChloramphenicol O-AcetyltransferaseEnhancer Elements, GeneticEpstein-Barr Virus Nuclear AntigensHerpesvirus 4, HumanHumansImmunoglobulin EIntronsMolecular Sequence DataReceptors, FcReceptors, IgERNA, MessengerTranscription, GeneticConceptsRegulatory elementsTranscriptional activationSpecific DNA-protein complexesIntron 1DNA-protein complexesMaintenance of immortalizationTranscriptional regulatory elementsMobility shift assaysReporter gene assayNuclear runoff analysisAdjacent flanking regionsTranscriptional regulationLymphoma linesIntron sequencesNuclear proteinsShift assaysFirst intronEnhancer activityHeterologous promoterReporter geneFlanking regionsEnhancer elementsMolecular mechanismsGene assayGenes
1991
Conversion of a human B cell lymphoma line by Epstein-Barr virus is associated with increased tyrosine phosphorylation of a 50 kilodalton cytosolic protein
Lacy J, Bartiss A, Coleman D. Conversion of a human B cell lymphoma line by Epstein-Barr virus is associated with increased tyrosine phosphorylation of a 50 kilodalton cytosolic protein. Virus Research 1991, 20: 85-96. PMID: 1656626, DOI: 10.1016/0168-1702(91)90063-2.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusB cellsHuman B cellsB-cell lymphoma linePresence of EBVLymphoma linesProtein tyrosine phosphorylationEBV infectionHuman B cell lymphoma lineTyrosine phosphorylationB lymphocytesImmortalized lymphoblastoid cellsBiochemical changesLymphoblastoid cellsInfectionEndogenous tyrosine kinasesContinuous proliferationCytosolic proteinsTyrosine kinaseVirusCellsPhosphorylationPhosphotyrosine antibodiesLymphocytesProtein
1989
Post‐transcriptional mechanisms of deregulation of MYC following conversion of a human B cell line by Epstein‐Barr virus.
Lacy J, Summers W, Summers W. Post‐transcriptional mechanisms of deregulation of MYC following conversion of a human B cell line by Epstein‐Barr virus. The EMBO Journal 1989, 8: 1973-1980. PMID: 2551670, PMCID: PMC401064, DOI: 10.1002/j.1460-2075.1989.tb03603.x.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusB cell linesBJAB cellsNegative Burkitt lymphoma linesPresence of EBVLymphoma linesBurkitt lymphoma linesCell linesNormal human B cellsHuman B cell linesHuman B cellsMYC mRNAEBV genomeVitro infectionMyc transcriptsB cellsEBVLymphoblastoid linesMYC expressionVirusMechanism of deregulationCellsPost-transcriptional mechanismsMYC