2000
Antisense to the Epstein‐Barr virus (EBV)‐encoded latent membrane protein 1 (LMP‐1) sensitizes EBV‐immortalized B cells to transforming growth factor‐beta and chemotherapeutic agents
Kenney J, Guinness M, Reiss M, Lacy J. Antisense to the Epstein‐Barr virus (EBV)‐encoded latent membrane protein 1 (LMP‐1) sensitizes EBV‐immortalized B cells to transforming growth factor‐beta and chemotherapeutic agents. International Journal Of Cancer 2000, 91: 89-98. PMID: 11149426, DOI: 10.1002/1097-0215(20010101)91:1<89::aid-ijc1015>3.0.co;2-u.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Agents, HormonalAntineoplastic Agents, PhytogenicApoptosisB-LymphocytesCell DivisionCell Line, TransformedCell SeparationCyclin D2CyclinsDexamethasoneDNA, AntisenseDown-RegulationEtoposideFlow CytometryHumansImmunoblottingLymphomaMyeloid Cell Leukemia Sequence 1 ProteinNeoplasm ProteinsProto-Oncogene Proteins c-bcl-2Transforming Growth Factor betaTumor Cells, CulturedVincristineViral Matrix ProteinsConceptsLatent membrane protein 1Epstein-Barr virusLymphoblastoid cell linesLMP-1B cellsMembrane protein 1Antisense oligodeoxynucleotidesEBV-positive lymphoproliferative disordersChemotherapeutic agentsEBV-positive lymphoblastoid cell linesEBV-positive cell linesProtein 1Human B cell growthAntisense treatmentApoptotic effectsRational therapeutic targetShort-term treatmentLMP-1 expressionRational therapeutic strategiesB cell growthCell linesLMP-1 proteinTumor necrosis factor receptor familyInhibition of proliferationLymphoproliferative disorders
1994
Epstein-Barr viral nuclear antigen 1 antisense oligodeoxynucleotide inhibits proliferation of Epstein-Barr virus-immortalized B cells.
Roth G, Curiel T, Lacy J. Epstein-Barr viral nuclear antigen 1 antisense oligodeoxynucleotide inhibits proliferation of Epstein-Barr virus-immortalized B cells. Blood 1994, 84: 582-7. PMID: 8025284, DOI: 10.1182/blood.v84.2.582.bloodjournal842582.Peer-Reviewed Original ResearchConceptsEBNA-1EBNA-1 proteinAntisense oligodeoxynucleotidesEpstein-Barr virus-immortalized B cellsEpstein-Barr virus nuclear antigen 1EBV-negative cellsLatent viral proteinsNuclear antigen 1Potential therapeutic implicationsLymphoblastoid cellsEpisomal viral genomesUnmodified antisense oligodeoxynucleotidesNeoplastic diseaseTherapeutic implicationsB cellsInhibited proliferationEBVEffect of antisenseAntigen 1Antiproliferative effectsProtein expressionUntreated cellsImmortalized cellsViral proteinsProliferationEpstein-Barr Viral Nuclear Antigen 1 Antisense Oligodeoxynucleotide Inhibits Proliferation of Epstein-Barr Virus-Immortalized B Cells
Roth G, Curiel T, Lacy J. Epstein-Barr Viral Nuclear Antigen 1 Antisense Oligodeoxynucleotide Inhibits Proliferation of Epstein-Barr Virus-Immortalized B Cells. Blood 1994, 84: 582-587. DOI: 10.1182/blood.v84.2.582.582.Peer-Reviewed Original ResearchEBNA-1EBNA-1 proteinAntisense oligodeoxynucleotidesEpstein-Barr virus nuclear antigen 1EBV-negative cellsEpstein-Barr virusLatent viral proteinsNuclear antigen 1Potential therapeutic implicationsLymphoblastoid cellsImmortalized B cellsEpisomal viral genomesUnmodified antisense oligodeoxynucleotidesNeoplastic diseaseTherapeutic implicationsB cellsInhibited proliferationInhibits proliferationEBVEffect of antisenseAntigen 1Antiproliferative effectsProtein expressionUntreated cellsImmortalized cells