ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions
Eckert M, Santiago-Medina M, Lwin T, Kim J, Courtneidge S, Yang J. ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions. Journal Of Cell Science 2017, 130: 2036-2048. PMID: 28468988, PMCID: PMC5482979, DOI: 10.1242/jcs.198200.Peer-Reviewed Original ResearchMeSH KeywordsADAM12 ProteinAnimalsBreast NeoplasmsCell AdhesionCell LineCell Line, TumorCell MovementCell SizeCells, CulturedEpithelial-Mesenchymal TransitionExtracellular MatrixFemaleFocal AdhesionsGene Expression Regulation, NeoplasticHEK293 CellsHumansMammary Neoplasms, AnimalMiceMutagenesis, Site-DirectedNeoplasm InvasivenessNeoplasm MetastasisNeoplasm TransplantationNuclear ProteinsProtein DomainsSignal TransductionTwist-Related Protein 1ConceptsFocal adhesionsEpithelial-mesenchymal transitionMetalloproteinase domainOverall cell adhesionFocal adhesion turnoverRegulation of invadopodiaMammary organoid culturesLive-imaging analysisTwist1 transcription factorMatrix degradationTumor invasionAdhesion turnoverPrimary tumor formationExtracellular matrix degradationInvadopodia formationTranscription factorsTranscription targetsInvadopodiaCell invasionBreast cancer cellsCell adhesionExpression levelsTumor formationPromotes Tumor InvasionCancer cells