Dependency of the Cancer-Specific Transcriptional Regulation Circuitry on the Promoter DNA Methylome
Liu Y, Liu Y, Huang R, Song W, Wang J, Xiao Z, Dong S, Yang Y, Yang X. Dependency of the Cancer-Specific Transcriptional Regulation Circuitry on the Promoter DNA Methylome. Cell Reports 2019, 26: 3461-3474.e5. PMID: 30893615, DOI: 10.1016/j.celrep.2019.02.084.Peer-Reviewed Original ResearchConceptsDNA methylomeTranscription factorsTranscriptional regulation circuitsCpG sitesGene expression dysregulationIntegrative analysis pipelineCpG methylation profilesSignature of cancerRegulation machineryExpression regulationCancer Genome AtlasCancer-related genesGene expression abnormalitiesExpression dysregulationMethylation profilesMethylomeDynamic dysregulationPhysiological relevanceGenome AtlasExpression abnormalitiesAnalysis pipelineRegulation circuitCancer typesDysregulationComprehensive understanding