2016
The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization
Zhang F, Prahst C, Mathivet T, Pibouin-Fragner L, Zhang J, Genet G, Tong R, Dubrac A, Eichmann A. The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization. Nature Communications 2016, 7: 13517. PMID: 27882935, PMCID: PMC5123080, DOI: 10.1038/ncomms13517.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCapillary PermeabilityDiabetic RetinopathyIntercellular Signaling Peptides and ProteinsMiceMice, KnockoutNeovascularization, PathologicNerve Tissue ProteinsNetrin ReceptorsOxygen Inhalation TherapyPhosphorylationReceptors, Cell SurfaceReceptors, ImmunologicRetinal DiseasesRetinopathy of PrematuritySignal TransductionVascular Endothelial Growth Factor Receptor-2Wound HealingConceptsCytoplasmic domainOxygen-induced retinopathyVascular permeabilityRetinopathy of prematurityTransmembrane receptorsWound healingDiabetic wound healingCutaneous wound healingDiabetic patientsUNC5B receptorRobo4Transgenic miceTissue revascularizationRevascularizationVessel permeabilityRetinopathyMiceHealingNeovascularizationReceptorsDomainPhosphorylationDeletionPrematurityPathway
2014
Netrin-1 controls sympathetic arterial innervation
Brunet I, Gordon E, Han J, Cristofaro B, Broqueres-You D, Liu C, Bouvrée K, Zhang J, del Toro R, Mathivet T, Larrivée B, Jagu J, Pibouin-Fragner L, Pardanaud L, Machado MJ, Kennedy TE, Zhuang Z, Simons M, Levy BI, Tessier-Lavigne M, Grenz A, Eltzschig H, Eichmann A. Netrin-1 controls sympathetic arterial innervation. Journal Of Clinical Investigation 2014, 124: 3230-3240. PMID: 24937433, PMCID: PMC4071369, DOI: 10.1172/jci75181.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornDCC ReceptorFemaleGrowth ConesMaleMesenteric ArteriesMiceMice, KnockoutMice, Mutant StrainsMice, TransgenicModels, NeurologicalMyocytes, Smooth MuscleNerve Growth FactorsNetrin-1PregnancyReceptors, Cell SurfaceSympathetic Nervous SystemTumor Suppressor ProteinsVasoconstrictionConceptsSmooth muscle cellsArterial innervationNetrin-1Resistance arteriesAutonomic sympathetic nervesArterial smooth muscle cellsPeripheral resistance arteriesBlood flow regulationOnset of innervationBlood flow controlCell type-specific deletionAxon guidance cue netrin-1Guidance cue netrin-1Sympathetic nervesSympathetic innervationVascular toneColorectal cancerPeripheral organsSympathetic neuronsBlood supplyInnervationMuscle cellsSympathetic growth conesArteryGrowth cones