Tumor suppressor CEBPA interacts with and inhibits DNMT3A activity
Chen X, Zhou W, Song R, Liu S, Wang S, Chen Y, Gao C, He C, Xiao J, Zhang L, Wang T, Liu P, Duan K, Cheng Z, Zhang C, Zhang J, Sun Y, Jackson F, Lan F, Liu Y, Xu Y, Wong J, Wang P, Yang H, Xiong Y, Chen T, Li Y, Ye D. Tumor suppressor CEBPA interacts with and inhibits DNMT3A activity. Science Advances 2022, 8: eabl5220. PMID: 35080973, PMCID: PMC8791617, DOI: 10.1126/sciadv.abl5220.Peer-Reviewed Original ResearchDNA methyltransferasesDNA methylationDe novo DNA methylationMammalian embryonic developmentNovo DNA methylationPRC2 target genesLonger splice isoformsCCAAT/enhancer binding protein αAberrant DNA methylationEnhancer binding protein αDNMT3A activityDNMT3a isoformsDNA substratesEmbryonic developmentSpecific lociTarget genesSplice isoformsDNA-hypomethylating agentN-terminusShort isoformProtein αMethylationFunctional differencesIsoformsMutations