The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination
Beilinson HA, Glynn RA, Yadavalli AD, Xiao J, Corbett E, Saribasak H, Arya R, Miot C, Bhattacharyya A, Jones JM, Pongubala JMR, Bassing CH, Schatz DG. The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination. Journal Of Experimental Medicine 2021, 218: e20210250. PMID: 34402853, PMCID: PMC8374863, DOI: 10.1084/jem.20210250.Peer-Reviewed Original ResearchThe activation mechanisms of master kinases in the DNA damage response
Xiao J, Rao Q, Xu Y. The activation mechanisms of master kinases in the DNA damage response. Genome Instability & Disease 2021, 2: 211-224. DOI: 10.1007/s42764-021-00045-y.Peer-Reviewed Original ResearchDNA damage responsePIKK regulatory domainDNA-PKDamage responseMultiple DNA repair pathwaysDNA damageStructures of ATMCryo-electron microscopyDNA repair pathwaysSeries of proteinsKinase structureMaster kinaseRegulatory domainRepair pathwaysGenetic informationCritical kinaseMolecular mechanismsSophisticated mechanismsExtrinsic stimuliActivation mechanismKinaseCritical roleATRPathwayEukaryotes