2024
Chapter 2 The Mechanism, Regulation and Evolution of V(D)J Recombination
Schatz D, Zhang Y, Xiao J, Zha S, Zhang Y, Alt F. Chapter 2 The Mechanism, Regulation and Evolution of V(D)J Recombination. 2024, 13-57. DOI: 10.1016/b978-0-323-95895-0.00004-0.Peer-Reviewed Original ResearchAntigen receptor lociNon-homologous end joiningChromatin loop extrusionRecombination-activating geneLoop extrusionV(D)J recombinationRecombination-activating gene proteinV(D)J recombination reactionReceptor locusEnd joiningDouble-strand (ds) DNA breaksLoop extrusion mechanismRegulation of recombinationRepertoire of antigen receptorsLymphocyte developmentOncogenic chromosomal translocationsVariable region gene segmentsDNA repair proteinsDNA repair pathwaysChromatin accessibilityDNA segmentsV(D)J recombinase activitySubstrate DNALoop domainV(D)J junctions
2021
The activation mechanisms of master kinases in the DNA damage response
Xiao J, Rao Q, Xu Y. The activation mechanisms of master kinases in the DNA damage response. Genome Instability & Disease 2021, 2: 211-224. DOI: 10.1007/s42764-021-00045-y.Peer-Reviewed Original ResearchDNA damage responsePIKK regulatory domainDNA-PKDamage responseMultiple DNA repair pathwaysDNA damageStructures of ATMCryo-electron microscopyDNA repair pathwaysSeries of proteinsKinase structureMaster kinaseRegulatory domainRepair pathwaysGenetic informationCritical kinaseMolecular mechanismsSophisticated mechanismsExtrinsic stimuliActivation mechanismKinaseCritical roleATRPathwayEukaryotes