2022
MIF is a common genetic determinant of COVID-19 symptomatic infection and severity
Shin JJ, Fan W, Par-Young J, Piecychna M, Leng L, Israni-Winger K, Qing H, Gu J, Zhao H, Schulz WL, Unlu S, Kuster J, Young G, Liu J, Ko AI, Garcia A, Sauler M, Wisnewski AV, Young L, Orduña A, Wang A, Klementina O, Garcia AB, Hegyi P, Armstrong ME, Mitchell P, Ordiz DB, Garami A, Kang I, Bucala R. MIF is a common genetic determinant of COVID-19 symptomatic infection and severity. QJM 2022, 116: 205-212. PMID: 36222594, PMCID: PMC9620729, DOI: 10.1093/qjmed/hcac234.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorLow-expression MIF alleleCOVID-19 infectionMIF allelesCATT7 alleleHealthy controlsCOVID-19Serum macrophage migration inhibitory factorSymptomatic SARS-CoV-2 infectionHigher serum MIF levelsHigh-expression MIF allelesRetrospective case-control studySARS-CoV-2 infectionFunctional polymorphismsAvailable clinical characteristicsMultinational retrospective studySerum MIF levelsUninfected healthy controlsSymptomatic COVID-19Tertiary medical centerHealthy control subjectsCase-control studyMigration inhibitory factorCoronavirus disease 2019Common functional polymorphisms
2019
A statistical framework for cross-tissue transcriptome-wide association analysis
Hu Y, Li M, Lu Q, Weng H, Wang J, Zekavat SM, Yu Z, Li B, Gu J, Muchnik S, Shi Y, Kunkle BW, Mukherjee S, Natarajan P, Naj A, Kuzma A, Zhao Y, Crane PK, Lu H, Zhao H. A statistical framework for cross-tissue transcriptome-wide association analysis. Nature Genetics 2019, 51: 568-576. PMID: 30804563, PMCID: PMC6788740, DOI: 10.1038/s41588-019-0345-7.Peer-Reviewed Original ResearchMeSH KeywordsGene ExpressionGene Expression ProfilingGenome-Wide Association StudyGenotypeHumansModels, GeneticPolymorphism, Single NucleotideTranscriptomeConceptsTranscriptome-wide association analysisAssociation analysisGene-trait associationsGene expression dataGene expression levelsGenetic architectureComplex traitsMore genesGene expressionSingle tissueExpression dataAssociation resultsExpression levelsPowerful approachImputation modelHuman tissuesImputation accuracyGenotypesStatistical frameworkTissueGenesKey componentTraitsPowerful metricExpression
2010
Evolution of peroxisome proliferator-activated receptor gamma alternative splicing.
Dou T, Xu J, Gao Y, Gu J, Ji C, Xie Y, Zhou Y. Evolution of peroxisome proliferator-activated receptor gamma alternative splicing. Frontiers In Bioscience-Elite 2010, 2: 1334-43. PMID: 20515805, DOI: 10.2741/e193.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingAnimalsEvolution, MolecularExonsHumansPolymorphism, Single NucleotidePPAR gammaConceptsKa/KsGamma geneHigher Ka/KsAlternative splicing exonsDifferent transcript variantsPPAR-gamma geneAdaptive evolutionVertebrate speciesAlternative splicingEvolutionary changeAlternative exonsEST dataGenomic sequencesNew exonsPeroxisome proliferator-activated receptor gammaTranscript variantsProliferator-activated receptor gammaConstitutive counterpartExonsGenesReceptor gammaGlucose homeostasisVertebratesImportant roleSplicing