2020
Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors
Schalper KA, Carleton M, Zhou M, Chen T, Feng Y, Huang SP, Walsh AM, Baxi V, Pandya D, Baradet T, Locke D, Wu Q, Reilly TP, Phillips P, Nagineni V, Gianino N, Gu J, Zhao H, Perez-Gracia JL, Sanmamed MF, Melero I. Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors. Nature Medicine 2020, 26: 688-692. PMID: 32405062, PMCID: PMC8127102, DOI: 10.1038/s41591-020-0856-x.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntineoplastic Agents, ImmunologicalBiomarkers, PharmacologicalBiomarkers, TumorCell Cycle CheckpointsCohort StudiesFemaleHumansInterleukin-8MaleNeoplasmsNeutrophil InfiltrationNeutrophilsPrognosisProtein Kinase InhibitorsRetrospective StudiesSurvival AnalysisTreatment FailureTumor MicroenvironmentUp-RegulationConceptsSerum IL-8 levelsImmune checkpoint inhibitorsIL-8 levelsAdvanced cancerSerum interleukin-8 levelsPhase 3 clinical trialsSerum interleukin-8Interleukin-8 levelsLarge-scale retrospective analysisNeutrophil infiltrationWorse prognosisClinical benefitPoor outcomeIndependent biomarkerTumor immunobiologyClinical trialsInterleukin-8Retrospective analysisPatientsCancerInhibitorsIpilimumabNivolumabEverolimusPrognosis
2016
Regulation of CBL and ESR1 expression by microRNA-22-3p, 513a-5p and 625-5p may impact the pathogenesis of dust mite-induced pediatric asthma
Dong X, Xu M, Ren Z, Gu J, Lu M, Lu Q, Zhong N. Regulation of CBL and ESR1 expression by microRNA-22-3p, 513a-5p and 625-5p may impact the pathogenesis of dust mite-induced pediatric asthma. International Journal Of Molecular Medicine 2016, 38: 446-456. PMID: 27277384, PMCID: PMC4935459, DOI: 10.3892/ijmm.2016.2634.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAsthmaCase-Control StudiesChildCytokinesDemographyDown-RegulationErbB ReceptorsEstrogen Receptor alphaFemaleGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksHumansInflammation MediatorsMaleMicroRNAsNF-kappa BPhosphatidylinositol 3-KinasesProto-Oncogene MasProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-cblPyroglyphidaeReal-Time Polymerase Chain ReactionRNA, MessengerSyk KinaseUp-RegulationConceptsPediatric asthmaPlasma concentrationsGender-matched healthy controlsCbl proto-oncogeneMite-induced asthmaPeroxisome proliferator-activated receptorInflammatory cytokine pathwaysMicroRNA-22-3pTumor necrosis factorProliferator-activated receptorEnzyme-linked immunosorbentRegulation of CblMiR-22-3pAsthma groupIL-10Asthma attacksHealthy controlsCytokine pathwaysNecrosis factorEstrogen receptorImmune responseESR1 expressionAsthmaControl groupInvolvement of microRNAs