2020
The role of the gut microbiome in cancer-related fatigue: pilot study on epigenetic mechanisms
Xiao C, Fedirko V, Beitler J, Bai J, Peng G, Zhou C, Gu J, Zhao H, Lin IH, Chico CE, Jeon S, Knobf TM, Conneely KN, Higgins K, Shin DM, Saba N, Miller A, Bruner D. The role of the gut microbiome in cancer-related fatigue: pilot study on epigenetic mechanisms. Supportive Care In Cancer 2020, 29: 3173-3182. PMID: 33078326, PMCID: PMC8055716, DOI: 10.1007/s00520-020-05820-3.Peer-Reviewed Original ResearchConceptsCancer-related fatigueGut microbiomePilot studyHigh-fatigue groupLow-fatigue groupsGut-brain axisMultidimensional Fatigue InventoryGut microbiota patternBrain healthCancer patientsFatigue InventoryNeck cancerPurposeRecent evidenceStool samplesImmune responseMicrobiota patternsGut microbiotaInflammationOne monthBrain functionPatientsConclusionsOur resultsFatty acid synthesisEPIC BeadChipDNA methylation changes
2016
Regulation of CBL and ESR1 expression by microRNA-22-3p, 513a-5p and 625-5p may impact the pathogenesis of dust mite-induced pediatric asthma
Dong X, Xu M, Ren Z, Gu J, Lu M, Lu Q, Zhong N. Regulation of CBL and ESR1 expression by microRNA-22-3p, 513a-5p and 625-5p may impact the pathogenesis of dust mite-induced pediatric asthma. International Journal Of Molecular Medicine 2016, 38: 446-456. PMID: 27277384, PMCID: PMC4935459, DOI: 10.3892/ijmm.2016.2634.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAsthmaCase-Control StudiesChildCytokinesDemographyDown-RegulationErbB ReceptorsEstrogen Receptor alphaFemaleGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksHumansInflammation MediatorsMaleMicroRNAsNF-kappa BPhosphatidylinositol 3-KinasesProto-Oncogene MasProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-cblPyroglyphidaeReal-Time Polymerase Chain ReactionRNA, MessengerSyk KinaseUp-RegulationConceptsPediatric asthmaPlasma concentrationsGender-matched healthy controlsCbl proto-oncogeneMite-induced asthmaPeroxisome proliferator-activated receptorInflammatory cytokine pathwaysMicroRNA-22-3pTumor necrosis factorProliferator-activated receptorEnzyme-linked immunosorbentRegulation of CblMiR-22-3pAsthma groupIL-10Asthma attacksHealthy controlsCytokine pathwaysNecrosis factorEstrogen receptorImmune responseESR1 expressionAsthmaControl groupInvolvement of microRNAs