Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery
Zhou J, Liu J, Cheng CJ, Patel TR, Weller CE, Piepmeier JM, Jiang Z, Saltzman WM. Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery. Nature Materials 2011, 11: 82-90. PMID: 22138789, PMCID: PMC4180913, DOI: 10.1038/nmat3187.Peer-Reviewed Original ResearchConceptsGene deliveryNon-viral gene deliveryEfficient gene deliveryGene delivery abilityTargeted gene deliveryHighest molecular weight terpolymerDelivery abilityTargeted deliveryLipofectamine 2000Dialkyl diesterVivo applicationsPolycationic vectorsSpecific ring sizesTRAIL geneHigh efficiencyCharge densityLow charge densityDeliveryPolyethylenimineMinimal toxicityEfficiencyHydrophobicityLactone contentDensityApplications