2019
Loss of STEP61 couples disinhibition to N-methyl-d-aspartate receptor potentiation in rodent and human spinal pain processing
Dedek A, Xu J, Kandegedara CM, Lorenzo LÉ, Godin AG, De Koninck Y, Lombroso PJ, Tsai EC, Hildebrand ME. Loss of STEP61 couples disinhibition to N-methyl-d-aspartate receptor potentiation in rodent and human spinal pain processing. Brain 2019, 142: 1535-1546. PMID: 31135041, PMCID: PMC6536915, DOI: 10.1093/brain/awz105.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptorsLaminae INMDAR responsesDorsal horn synapsesSpinal pain processingNerve injury modelSpinal dorsal hornSynaptic NMDAR responsesTyrosine phosphatase STEP61Loss of inhibitionBehavioral hypersensitivityInflammatory painNeuropathic painDorsal hornPain statesPathological painPain targetsChronic painPain processingInjury modelAssociated downregulationRodent modelsReceptor potentiationPainSTEP61 activity
2001
Cloning, expression and characterization of a novel human REPS1 gene1The nucleotide sequence reported in this paper has been submitted to GenBank under accession number AF251052.1
Xu J, Zhou Z, Zeng L, Huang Y, Zhao W, Cheng C, Xu M, Xie Y, Mao Y. Cloning, expression and characterization of a novel human REPS1 gene1The nucleotide sequence reported in this paper has been submitted to GenBank under accession number AF251052.1. Biochimica Et Biophysica Acta 2001, 1522: 118-121. PMID: 11750063, DOI: 10.1016/s0167-4781(01)00310-4.Peer-Reviewed Original ResearchConceptsHuman fetal brain libraryFetal brain libraryAmino acid identitySignal transduction pathwaysDownstream target proteinsNorthern blot analysisProtein familySmall GTPaseBinding partnerAcid identityTransduction pathwaysNucleotide sequenceVariety of tissuesBrain libraryTarget proteinsReps1Blot analysisProteinRalBP1Recent findingsStrong expressionExpressionRalGTPaseImportant role