2020
Inhibition of striatal-enriched protein tyrosine phosphatase (STEP) activity reverses behavioral deficits in a rodent model of autism
Chatterjee M, Singh P, Xu J, Lombroso PJ, Kurup PK. Inhibition of striatal-enriched protein tyrosine phosphatase (STEP) activity reverses behavioral deficits in a rodent model of autism. Behavioural Brain Research 2020, 391: 112713. PMID: 32461127, PMCID: PMC7346720, DOI: 10.1016/j.bbr.2020.112713.Peer-Reviewed Original ResearchAnimalsAutism Spectrum DisorderAutistic DisorderBehavior, AnimalDisease Models, AnimalExploratory BehaviorFemaleInhibition, PsychologicalMaleMiceMice, Inbred C57BLNeuronal PlasticityPrefrontal CortexPregnancyPrenatal Exposure Delayed EffectsProtein Tyrosine PhosphatasesProtein Tyrosine Phosphatases, Non-ReceptorSocial BehaviorStereotyped BehaviorValproic Acid
2012
The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications
Carty NC, Xu J, Kurup P, Brouillette J, Goebel-Goody SM, Austin DR, Yuan P, Chen G, Correa PR, Haroutunian V, Pittenger C, Lombroso PJ. The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications. Translational Psychiatry 2012, 2: e137-e137. PMID: 22781170, PMCID: PMC3410627, DOI: 10.1038/tp.2012.63.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptorsSTEP61 levelsSurface expressionPostmortem anterior cingulate cortexGluN2B-containing N-methyl-D-aspartate receptorsGluN1/GluN2B receptorsMK-801 treatmentPathophysiology of schizophreniaAnterior cingulate cortexSTEP knockout miceDorsolateral prefrontal cortexChronic administrationChronic treatmentNeuroleptic treatmentAntipsychotic medicationGlutamatergic functionMK-801Glutamate hypothesisMedications resultsTyrosine phosphatase STEPGlutamatergic signalingKnockout miceGluN2B receptorsCingulate cortexSynaptic plasticity
2010
The role of STEP in Alzheimer's disease
Kurup P, Zhang Y, Venkitaramani DV, Xu J, Lombroso PJ. The role of STEP in Alzheimer's disease. Channels 2010, 4: 347-350. PMID: 20699650, PMCID: PMC3230511, DOI: 10.4161/chan.4.5.12910.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate (NMDA) type glutamate receptorsAlzheimer's diseaseProtein tyrosine Phosphatase 61AD prefrontal cortexAD mouse modelType glutamate receptorsGlutamate receptor traffickingNeuronal surface membraneNMDAR internalizationAβ treatmentPutative causative agentGlutamate receptorsMouse modelCulture resultsGluN1/Prefrontal cortexDiseaseNeuronal membranesNMDAR endocytosisAdditional studiesAβCausative agentSurface expressionUbiquitin-proteasome systemReceptor complex