Striatal-Enriched Protein Tyrosine Phosphatase in Alzheimer’s Disease
Xu J, Kurup P, Nairn AC, Lombroso PJ. Striatal-Enriched Protein Tyrosine Phosphatase in Alzheimer’s Disease. Advances In Pharmacology 2012, 64: 303-325. PMID: 22840751, PMCID: PMC3740556, DOI: 10.1016/b978-0-12-394816-8.00009-x.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseNeurofibrillary tanglesStriatal-enriched protein tyrosine phosphataseAmyloid plaquesTreatment of ADHyperphosphorylated tau proteinSubstantial economic burdenProgressive diseasePotential clinical applicationsClinical symptomsBeta amyloidGlutamate receptorsEconomic burdenTau proteinCortical accumulationCognitive functionMemory lossBeneficial effectsDiseaseNeuronal membranesCommon formMultiple intracellularMillions of peopleClinical applicationImportant target