Regulation of STEP61 and tyrosine-phosphorylation of NMDA and AMPA receptors during homeostatic synaptic plasticity
Jang SS, Royston SE, Xu J, Cavaretta JP, Vest MO, Lee KY, Lee S, Jeong HG, Lombroso PJ, Chung HJ. Regulation of STEP61 and tyrosine-phosphorylation of NMDA and AMPA receptors during homeostatic synaptic plasticity. Molecular Brain 2015, 8: 55. PMID: 26391783, PMCID: PMC4578242, DOI: 10.1186/s13041-015-0148-4.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptorsHomeostatic synaptic plasticitySynaptic plasticityTyrosine phosphorylationActivity blockadeDephosphorylation of GluN2BSynaptic scalingProtein tyrosine phosphataseLevel of GluN2BProlonged activity blockadeExcitatory synaptic transmissionHippocampal cultured neuronsIsoxazolepropionic acid (AMPA) receptorsNMDAR subunit GluN2BActivity-dependent regulationTyrosine phosphataseSTEP61 levelsHomeostatic stabilizationSynaptic transmissionExcitatory synapsesAMPA receptorsGluA2 expressionPostsynaptic accumulationCultured neuronsAcid receptors