Reduced levels of the tyrosine phosphatase STEP block beta amyloid‐mediated GluA1/GluA2 receptor internalization
Zhang Y, Kurup P, Xu J, Anderson GM, Greengard P, Nairn AC, Lombroso PJ. Reduced levels of the tyrosine phosphatase STEP block beta amyloid‐mediated GluA1/GluA2 receptor internalization. Journal Of Neurochemistry 2011, 119: 664-672. PMID: 21883219, PMCID: PMC3192910, DOI: 10.1111/j.1471-4159.2011.07450.x.Peer-Reviewed Original ResearchConceptsAD mouse modelMouse modelTriple transgenic AD mouse modelAlzheimer's diseaseTransgenic AD mouse modelGluA2 receptorsAD prefrontal cortexElevated levelsGluA1/GluA2Cortical culturesBeta amyloidRegulate surface expressionCognitive deficitsStriatal-enriched protein tyrosine phosphatasePrefrontal cortexΑ-aminoReceptorsReceptor internalizationSurface expressionReduced levelsReceptor complexCortexDiseaseMiceAβ