2015
Striatal‐enriched protein tyrosine phosphatase regulates the PTPα/Fyn signaling pathway
Xu J, Kurup P, Foscue E, Lombroso PJ. Striatal‐enriched protein tyrosine phosphatase regulates the PTPα/Fyn signaling pathway. Journal Of Neurochemistry 2015, 134: 629-641. PMID: 25951993, PMCID: PMC4516628, DOI: 10.1111/jnc.13160.Peer-Reviewed Original ResearchConceptsProtein tyrosine phosphataseProtein kinase ARegulation of FynTyrosine phosphataseReceptor-type protein tyrosine phosphatase alphaProtein tyrosine phosphatase alphaStriatal-enriched protein tyrosine phosphataseRegulatory tyrosine residuesActivation of FynTyrosine kinase FynRegulatory tyrosineProtein tyrosinePTPαKinase FynSynaptic membranesKinase ATyrosine residuesFyn activityFynNovel substratePrimary neuronal culturesSTEP61Synergistic regulationMolecular techniquesNovel mechanism
2010
A STEP forward in neural function and degeneration
Baum ML, Kurup P, Xu J, Lombroso PJ. A STEP forward in neural function and degeneration. Communicative & Integrative Biology 2010, 3: 419-422. PMID: 21057629, PMCID: PMC2974069, DOI: 10.4161/cib.3.5.12692.Peer-Reviewed Original ResearchStriatal-enriched phosphataseProtein tyrosine phosphataseTyrosine kinase FynMAP kinases ERK1/2Tyrosine phosphataseKinase FynLocal translationKinases ERK1/2NR1/NR2BProteolytic cleavageNormal regulationNeurodegenerative diseasesSubunitsSynaptic plasticityPhosphataseRegulationGluR2 receptorsNR2B subunitSynaptic strengtheningUbiquitinationRecent progressNeural functionFynPhosphorylationGluR2 subunit