Cytomegalovirus IgG is Associated With Physical Function But Not Muscle Density in People With HIV
Abidi M, Umbleja T, Overton E, Burdo T, Flynn J, Lu M, Taron J, Schnittman S, Fitch K, Zanni M, Fichtenbaum C, Malvestutto C, Aberg J, Fulda E, Eckard A, Manne-Goehler J, Tuan J, Ribaudo H, Douglas P, Grinspoon S, Brown T, Erlandson K. Cytomegalovirus IgG is Associated With Physical Function But Not Muscle Density in People With HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2024, 95: 470-478. PMID: 38180893, PMCID: PMC10947880, DOI: 10.1097/qai.0000000000003377.Peer-Reviewed Original ResearchHigh-sensitivity C-reactive proteinShort Physical Performance BatteryCMV IgG titersPhysical functionMuscle densityIgG titersPhysical function impairmentAtherosclerotic cardiovascular diseasePhysical Performance BatteryPoor physical functionC-reactive proteinPhysical function measuresLog-binomial regressionPhysical function dataQuantitative enzyme immunoassayPartial Spearman correlationsNadir CD4CMV IgGCytomegalovirus seropositivityFurther mechanistic studiesSPPB scoreFunction impairmentPoor outcomePrimary preventionBiomarker testing