Acyl-CoA Dehydrogenase 9 Is Required for the Biogenesis of Oxidative Phosphorylation Complex I
Nouws J, Nijtmans L, Houten S, van den Brand M, Huynen M, Venselaar H, Hoefs S, Gloerich J, Kronick J, Hutchin T, Willems P, Rodenburg R, Wanders R, van den Heuvel L, Smeitink J, Vogel R. Acyl-CoA Dehydrogenase 9 Is Required for the Biogenesis of Oxidative Phosphorylation Complex I. Cell Metabolism 2010, 12: 283-294. PMID: 20816094, DOI: 10.1016/j.cmet.2010.08.002.Peer-Reviewed Original ResearchMeSH KeywordsAcyl-CoA Dehydrogenase, Long-ChainAcyl-CoA DehydrogenasesAdaptor Proteins, Signal TransducingAmino Acid SequenceAnimalsCells, CulturedElectron Transport Complex IFatty AcidsFemaleFibroblastsHumansInfantMaleMitochondriaModels, MolecularMolecular Sequence DataMutationNADH DehydrogenaseOxidation-ReductionOxidative PhosphorylationPhylogenyPregnancyProtein Structure, TertiaryRNA InterferenceSequence AnalysisSequence Analysis, DNAConceptsAcyl-CoA dehydrogenase 9Complex I deficiencyFatty acid oxidationComplex IOxidative phosphorylation complexes IAcyl-CoA dehydrogenase familyMitochondrial metabolic pathwaysI deficiencyLong-chain acyl-CoA dehydrogenaseAcid oxidationAcyl-CoA dehydrogenaseFactors NDUFAF1Vertebrate lineageDehydrogenase familyRelated metabolic enzymesLong-chain fatty acidsMetabolic enzymesOxidative phosphorylationLong-chain fatty acid oxidationMitochondrial beta oxidationMetabolic pathwaysACAD9 mutationsBeta oxidationFatty acidsNDUFAF1