Featured Publications
Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis
Barmada A, Klein J, Ramaswamy A, Brodsky N, Jaycox J, Sheikha H, Jones K, Habet V, Campbell M, Sumida T, Kontorovich A, Bogunovic D, Oliveira C, Steele J, Hall E, Pena-Hernandez M, Monteiro V, Lucas C, Ring A, Omer S, Iwasaki A, Yildirim I, Lucas C. Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis. Science Immunology 2023, 8: eadh3455-eadh3455. PMID: 37146127, PMCID: PMC10468758, DOI: 10.1126/sciimmunol.adh3455.Peer-Reviewed Original ResearchConceptsMRNA vaccinesSARS-CoV-2 mRNA vaccinesSARS-CoV-2 mRNA vaccinationC-reactive protein levelsB-type natriuretic peptidePeripheral blood mononuclear cellsCardiac tissue inflammationDeep immune profilingSerum soluble CD163Vaccine-associated myocarditisCohort of patientsBlood mononuclear cellsCytotoxic T cellsLate gadolinium enhancementHypersensitivity myocarditisElevated troponinMRNA vaccinationImaging abnormalitiesNK cellsImmune profilingKiller cellsMyeloid responseNatriuretic peptideHumoral mechanismsInflammatory cytokinesComprehensive Multimodality Imaging of Congenitally Corrected Transposition of the Great Arteries Incidentally Found to Have Coronary Ischemia
Sasse A, Feher A, Thorn S, Fahey J, Keeshan B, Sinusas A, Mojibian H, Steele J. Comprehensive Multimodality Imaging of Congenitally Corrected Transposition of the Great Arteries Incidentally Found to Have Coronary Ischemia. Circulation Cardiovascular Imaging 2023, 16: 597-600. PMID: 37092334, DOI: 10.1161/circimaging.122.015158.Peer-Reviewed Case Reports and Technical NotesComputed Tomographic 3-Dimensional Virtual Dissection Aiding in Diagnosis and Surgical Planning of a Rare Form of Obstructed Supracardiac Total Anomalous Pulmonary Venous Connection With an Unusual Scimitar-Like Arrangement
Leone DM, Gruber PJ, Pesce M, Lee M, Brown C, Ghiroli S, Steele JM. Computed Tomographic 3-Dimensional Virtual Dissection Aiding in Diagnosis and Surgical Planning of a Rare Form of Obstructed Supracardiac Total Anomalous Pulmonary Venous Connection With an Unusual Scimitar-Like Arrangement. World Journal For Pediatric And Congenital Heart Surgery 2022, 14: 233-235. PMID: 36322621, DOI: 10.1177/21501351221133771.Peer-Reviewed Case Reports and Technical NotesConceptsSupracardiac total anomalous pulmonary venous connectionTotal anomalous pulmonary venous connectionAnomalous pulmonary venous connectionPulmonary venous connectionVenous connectionTomographic angiographyObstructed supracardiac total anomalous pulmonary venous connectionComplex congenital heart diseaseSurgical planningCongenital heart diseaseMembrane oxygenationSurgical managementRare presentationPreoperative imagingExcellent outcomesHeart diseaseRare formAnatomical delineationDissection techniqueNoncardiac structuresPresurgical planningAdjustment of flowAngiographyTechnique aidsCOVID-19 Vaccination–Associated Myocarditis in Adolescents
Jain SS, Steele JM, Fonseca B, Huang S, Shah S, Maskatia SA, Buddhe S, Misra N, Ramachandran P, Gaur L, Eshtehardi P, Anwar S, Kaushik N, Han F, Chaudhuri NR, Grosse-Wortmann L. COVID-19 Vaccination–Associated Myocarditis in Adolescents. Pediatrics 2021, 148: e2021053427. PMID: 34389692, DOI: 10.1542/peds.2021-053427.Peer-Reviewed Original ResearchConceptsCardiovascular magnetic resonanceMultisystem inflammatory syndromeMyocardial tissue changesInflammatory syndromeVentricular dysfunctionMyocardial injuryTissue changesExcellent short-term outcomesMild left ventricular dysfunctionDifferent pediatric age groupsQuick clinical recoveryLeft ventricular dysfunctionResolution of symptomsRetrospective multicenter studyPediatric age groupShort-term outcomesShort-term prognosisMessenger RNA vaccinesLate gadolinium enhancementYears of ageLake Louise criteriaSignificant dysrhythmiasHospital courseClinical characteristicsClinical recoveryLeft atrial strain and diastolic function abnormalities in obese and type 2 diabetic adolescents and young adults
Steele JM, Urbina EM, Mazur WM, Khoury PR, Nagueh SF, Tretter JT, Alsaied T. Left atrial strain and diastolic function abnormalities in obese and type 2 diabetic adolescents and young adults. Cardiovascular Diabetology 2020, 19: 163. PMID: 33004030, PMCID: PMC7531140, DOI: 10.1186/s12933-020-01139-9.Peer-Reviewed Original ResearchConceptsConduit strain rateDiastolic function abnormalitiesLV diastolic functionDiastolic functionFunction abnormalitiesT2DM patientsYoung adultsLA volumeMultivariable analysisBooster strainLeft ventricular diastolic function abnormalitiesType 2 diabetic adolescentsType 2 diabetes mellitusMitral E/Normal LA volumePrevalence of diastolicStructurally normal heartsPrevalence of abnormalitiesSpeckle tracking measurementsAtrial strainAtrial functionDiabetes mellitusEchocardiographic measuresEjection fractionHeart failure
2022
Short-Term Outcomes After Myopericarditis Related to COVID-19 Vaccination
Pareek M, Steele J, Asnes J, Baldassarre L, Casale L, Desai N, Elder R, Faherty E, Ferguson I, Fishman R, Ghazizadeh Z, Glick L, Hall E, Khera R, Kokkinidis D, Kwan J, O'Marr J, Schussheim A, Tuohy E, Wang Y, Spatz E, Jacoby D, Miller E. Short-Term Outcomes After Myopericarditis Related to COVID-19 Vaccination. JACC Cardiovascular Imaging 2022, 15: 2002-2005. PMID: 36357140, PMCID: PMC9094612, DOI: 10.1016/j.jcmg.2022.03.026.Peer-Reviewed Case Reports and Technical Notes
2021
A 13-Year-Old With Fever and Chest Pain
Soma G, Simmons MA, Canarie MF, Karnik R, Steele J, Tiyyagura G, Asnes J. A 13-Year-Old With Fever and Chest Pain. Pediatrics 2021, 148: e2021050960. PMID: 34344802, DOI: 10.1542/peds.2021-050960.Peer-Reviewed Case Reports and Technical NotesUse of advanced cardiac imaging in congenital heart disease: growth, indications and innovations
Steele JM, Moore RA, Lang SM. Use of advanced cardiac imaging in congenital heart disease: growth, indications and innovations. Current Opinion In Pediatrics 2021, 33: 495-502. PMID: 34374664, DOI: 10.1097/mop.0000000000001051.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiac magnetic resonance imagingCardiac computed tomographyAdvanced cardiac imagingCongenital heart diseaseAdvanced imagingCHD patientsHeart diseaseCardiac imagingManagement of patientsAppropriate use criteriaLower radiation exposureMagnetic resonance imagingAugmented Reality PlatformSicker patientsComputed tomographyNoninvasive evaluationPatientsResonance imagingUse criteriaCMR techniquesRadiation exposureHigh-quality imagesReality platformDiseaseDigital technologies
2020
Atrial Function and Its Role in the Non-invasive Evaluation of Diastolic Function in Congenital Heart Disease
Ta HT, Alsaied T, Steele JM, Truong VT, Mazur W, Nagueh SF, Kutty S, Tretter JT. Atrial Function and Its Role in the Non-invasive Evaluation of Diastolic Function in Congenital Heart Disease. Pediatric Cardiology 2020, 41: 654-668. PMID: 32342149, DOI: 10.1007/s00246-020-02351-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCongenital heart diseaseAtrial functionDiastolic functionNon-invasive assessmentHeart diseaseDiastolic dysfunctionVentricular diastolic dysfunctionDiastolic function assessmentNon-invasive evaluationAtrial dysfunctionAdult patientsAtrial sizeAdverse outcomesConduit functionBody of evidenceContractile functionFunction assessmentCompensatory increaseDysfunctionCommon pathwayDiseaseAtrial formCurrent knowledgePivotal roleMost formsComputed Tomographic 3-Dimensional Virtual Dissection Aiding Surgical Planning in a Rare Pediatric Case of Bicuspid Aortic Valve With Ascending Aorta Pseudoaneurysm
Steele J, Alsaied T, Crotty EJ, Tretter JT. Computed Tomographic 3-Dimensional Virtual Dissection Aiding Surgical Planning in a Rare Pediatric Case of Bicuspid Aortic Valve With Ascending Aorta Pseudoaneurysm. Circulation Cardiovascular Imaging 2020, 13: e010089. PMID: 32114826, DOI: 10.1161/circimaging.119.010089.Peer-Reviewed Case Reports and Technical Notes
2019
Short‐term results in infants with multiple left heart obstructive lesions
Steele JM, Komarlu R, Worley S, Alsaied T, Statile C, Erenberg FG. Short‐term results in infants with multiple left heart obstructive lesions. Congenital Heart Disease 2019, 14: 1193-1198. PMID: 31489778, DOI: 10.1111/chd.12829.Peer-Reviewed Original ResearchMeSH KeywordsCardiac Surgical ProceduresChild, PreschoolEchocardiographyFemaleHeart Defects, CongenitalHeart VentriclesHumansInfantInfant, NewbornMalePalliative CareRecovery of FunctionRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeVentricular Function, LeftVentricular Function, RightConceptsHeart obstructive lesionsVentricular septal defectObstructive lesionsMultiple left heart obstructive lesionsAortic valve z-scoreLeft heart obstructive lesionsHybrid stage 1Mitral valve atresiaCritical aortic stenosisInitial surgical procedureSingle ventricle physiologySeptal defect closureSuccessful biventricular repairTricuspid valve annulus sizeShort-term resultsYears of ageEchocardiographic predictorsInitial echocardiogramBiventricular repairCardiac transplantationCoarctation repairVentricle physiologyAortic stenosisArch reconstructionClinical outcomesObesity trends in children, adolescents, and young adults with congenital heart disease
Steele JM, Preminger TJ, Erenberg FG, Wang L, Dell K, Alsaied T, Zahka KG. Obesity trends in children, adolescents, and young adults with congenital heart disease. Congenital Heart Disease 2019, 14: 517-524. PMID: 30698365, DOI: 10.1111/chd.12754.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseNormal weightHeart diseaseRisk factorsPrevalence of overweightRisk of obesityRange of overweightYears of ageAge of onsetCardiac careCounsel familiesCHD diagnosisElectrophysiologic diseaseObesity trendsOverweightObesityPatientsObeseOlder ageYoung adultsPreventative measuresDiseaseAgeEarly childhoodChildren
2018
Endocardial Coronary Artery: A Rare Congenital Coronary Anomaly
Steele JM, Zahka KG. Endocardial Coronary Artery: A Rare Congenital Coronary Anomaly. Pediatric Cardiology 2018, 40: 219-220. PMID: 30267109, DOI: 10.1007/s00246-018-1993-6.Peer-Reviewed Case Reports and Technical NotesConceptsCongenital coronary anomaliesRare congenital coronary anomalyExertional chest painCoronary anomaliesChest painCoronary anatomyPediatric chest painIntramural coronary arteriesSudden cardiac deathComputed tomography angiographyCardiology referralCardiac deathVentricular arrhythmiasMyocardial bridgeCoronary arteryTomography angiographyCommon reasonFurther evaluationPainAnatomyAnginaEchocardiographyProper delineationAngiographyArteryCongenital and Acquired Systemic Venous Anomalies: A Potpourri of Right to Left Shunts
Steele J, Prieto L, Majdalany D, Stewart R, Najm H, Yaman ME. Congenital and Acquired Systemic Venous Anomalies: A Potpourri of Right to Left Shunts. World Journal For Pediatric And Congenital Heart Surgery 2018, 11: np176-np181. PMID: 30222040, DOI: 10.1177/2150135118788786.Peer-Reviewed Case Reports and Technical NotesConceptsSystemic venous anomaliesVenous anomaliesSystemic veinsLeft superior venaCongenital heart diseaseLeft shuntVenous obstructionCoronary sinusVenous variantsCase seriesSuperior venaAnatomic evaluationHeart diseaseLeft atriumSitus solitusAccurate diagnosisDiagnostic testingBubble studyPatientsVeinShuntDiagnosisVenaPatencySinusLarge superior vena cava thrombus requiring thrombectomy as a complication of ventriculo‐atrial shunt
Steele J, Stewart R, Komarlu R, Najm H. Large superior vena cava thrombus requiring thrombectomy as a complication of ventriculo‐atrial shunt. Journal Of Cardiac Surgery 2018, 33: 397-398. PMID: 29900584, DOI: 10.1111/jocs.13737.Peer-Reviewed Case Reports and Technical NotesAnticoagulantsCardiac Surgical ProceduresChild, PreschoolEchocardiographyHeparinHumansMalePostoperative ComplicationsStaphylococcal InfectionsSuperior Vena Cava SyndromeSurgical Wound DehiscenceSurgical Wound InfectionThrombectomyTreatment OutcomeVancomycinVena Cava, SuperiorVentriculoperitoneal Shunt
2016
Pentalogy of Cantrell
Steele J, Stewart RD, Pettersson G, Attia T, Komarlu R, Edwards T. Pentalogy of Cantrell. World Journal For Pediatric And Congenital Heart Surgery 2016, 7: 525-526. PMID: 27358306, DOI: 10.1177/2150135116651096.Peer-Reviewed Case Reports and Technical Notes