2015
Prognostication of post-cardiac arrest coma: early clinical and electroencephalographic predictors of outcome
Sivaraju A, Gilmore EJ, Wira CR, Stevens A, Rampal N, Moeller JJ, Greer DM, Hirsch LJ, Gaspard N. Prognostication of post-cardiac arrest coma: early clinical and electroencephalographic predictors of outcome. Intensive Care Medicine 2015, 41: 1264-1272. PMID: 25940963, DOI: 10.1007/s00134-015-3834-x.Peer-Reviewed Original ResearchConceptsBetter outcomesPoor outcomeEpileptiform dischargesPost-cardiac arrest comatose patientsCritical care EEG terminologyPost-cardiac arrest comaMethodsProspective cohort studyContinuous EEG monitoringLow-voltage EEGPositive predictive valueAbsence of reactivityEEG terminologyCohort studySpontaneous circulationBrainstem reflexesClinical outcomesComatose patientsFalse positive ratePoor prognosisPrognostic significanceSuppression burstsClinical variablesClinical correlatesElectroencephalographic patternsElectroencephalographic predictors
2008
Lamotrigine–valproic acid combination therapy for medically refractory epilepsy
Moeller JJ, Rahey SR, Sadler RM. Lamotrigine–valproic acid combination therapy for medically refractory epilepsy. Epilepsia 2008, 50: 475-479. PMID: 19054403, DOI: 10.1111/j.1528-1167.2008.01866.x.Peer-Reviewed Original ResearchConceptsEpilepsy typeRefractory epilepsyAntiepileptic drugsCombination therapyPatient demographicsBaseline seizure frequencyRetrospective chart reviewPrimary outcome measureInclusion-exclusion criteriaVPA monotherapyChart reviewSeizure frequencyRetrospective studyMedical intractabilityClinic databaseUnimproved patientsOutcome measuresPatientsTherapyEpilepsyDemographicsSignificant differencesSeizuresMonthsSeverity