2010
Effects of Estradiol on Learned Helplessness and Associated Remodeling of Hippocampal Spine Synapses in Female Rats
Hajszan T, Szigeti-Buck K, Sallam NL, Bober J, Parducz A, MacLusky NJ, Leranth C, Duman RS. Effects of Estradiol on Learned Helplessness and Associated Remodeling of Hippocampal Spine Synapses in Female Rats. Biological Psychiatry 2010, 67: 168-174. PMID: 19811775, PMCID: PMC2794927, DOI: 10.1016/j.biopsych.2009.08.017.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsBehavior, AnimalCA1 Region, HippocampalDendritic SpinesDisease Models, AnimalElectroshockEscape ReactionEstradiolEstrogensFemaleHelplessness, LearnedMicroscopy, Electron, TransmissionNeuronsOvariectomyRatsRats, Sprague-DawleyRegression AnalysisStereotaxic TechniquesStress, PsychologicalSynapsesTime FactorsConceptsHippocampal spine synapsesSpine synapsesHelpless behaviorFemale ratsSpine synapse numberNeurobiology of depressionOvariectomized female ratsEffects of estradiolPresence of estradiolElectron microscopic stereologySynaptic lossSubchronic treatmentEstradiol exposureEstradiol supplementationFemale reproductive lifeNonstressed animalsSynaptic responsesSynaptogenic effectsDepression neurobiologyMale ratsSynapse numberAntidepressant desipramineEscape testingSynapse remodelingSignificant negative correlation
2008
Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates
Leranth C, Hajszan T, Szigeti-Buck K, Bober J, MacLusky NJ. Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 14187-14191. PMID: 18768812, PMCID: PMC2544599, DOI: 10.1073/pnas.0806139105.Peer-Reviewed Original ResearchConceptsSpine synapse formationNonhuman primate modelSynapse formationPrimate modelAbility of BPAPrefrontal cortexOvariectomized nonhuman primatesLimbic brain areasHuman BPA exposureRodent animal modelsLow exposure levelsBPA administrationDaily doseMale ratsSpine synapsesBPA exposureAnimal modelsBrain areasSynthetic xenoestrogenCognitive functionNonhuman primatesAdverse effectsExposure levelsPolycarbonate plasticsExposure measurements