2019
Regulation of substrate utilization and adiposity by Agrp neurons
Cavalcanti-de-Albuquerque JP, Bober J, Zimmer MR, Dietrich MO. Regulation of substrate utilization and adiposity by Agrp neurons. Nature Communications 2019, 10: 311. PMID: 30659173, PMCID: PMC6338802, DOI: 10.1038/s41467-018-08239-x.Peer-Reviewed Original ResearchConceptsFat mass accumulationAgRP neuronsPositive energy balanceWhole-body substrate utilizationAgRP neuron activationHypothalamic AgRP neuronsPair-feeding conditionsSubstrate utilizationFatty acid synthaseCaloric ingestionFat utilizationNeuronal mechanismsWeight gainNeuronsMetabolic changesMass accumulationKey enzymeAdiposityAcid synthaseEnergy metabolismNeuron activationLipogenesisActivationCarbohydrate utilizationMetabolic efficiency
2017
Puberty is an important developmental period for the establishment of adipose tissue mass and metabolic homeostasis
Holtrup B, Church CD, Berry R, Colman L, Jeffery E, Bober J, Rodeheffer MS. Puberty is an important developmental period for the establishment of adipose tissue mass and metabolic homeostasis. Adipocyte 2017, 6: 224-233. PMID: 28792785, PMCID: PMC5638358, DOI: 10.1080/21623945.2017.1349042.Peer-Reviewed Original ResearchConceptsChildhood obesityMetabolic dysfunctionMetabolic homeostasisObesogenic stimuliExposure of miceHigh-fat dietAdipose tissue functionAdipose tissue massPostnatal day 18White adipose tissueType II diabetesCritical developmental periodAdipose massFat dietLeptin expressionAdipocyte sizeFat massDiabetic phenotypeObesityTissue massAdipose tissueBody weightDay 18II diabetesAdipose function