Featured Publications
Comparative Effectiveness of Machine Learning Approaches for Predicting Gastrointestinal Bleeds in Patients Receiving Antithrombotic Treatment
Herrin J, Abraham NS, Yao X, Noseworthy PA, Inselman J, Shah ND, Ngufor C. Comparative Effectiveness of Machine Learning Approaches for Predicting Gastrointestinal Bleeds in Patients Receiving Antithrombotic Treatment. JAMA Network Open 2021, 4: e2110703. PMID: 34019087, PMCID: PMC8140376, DOI: 10.1001/jamanetworkopen.2021.10703.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnticoagulantsAntifibrinolytic AgentsAtrial FibrillationClinical Decision-MakingCohort StudiesCross-Sectional StudiesFemaleFibrinolytic AgentsGastrointestinal HemorrhageHumansMachine LearningMaleMiddle AgedMyocardial IschemiaPredictive Value of TestsRetrospective StudiesRisk AssessmentThienopyridinesUnited StatesVenous ThromboembolismYoung AdultConceptsGastrointestinal bleedingIschemic heart diseaseCross-sectional studyThienopyridine antiplatelet agentAntithrombotic treatmentVenous thromboembolismAntiplatelet agentsRandom survival forestStudy cohortAtrial fibrillationValidation cohortHeart diseaseHAS-BLED risk scoreRetrospective cross-sectional studyCox proportional hazards regressionHAS-BLED scorePrior GI bleedPatients 18 yearsCohort of patientsEntire study cohortProportional hazards regressionOptumLabs Data WarehouseMedicare Advantage enrolleesPositive predictive valueRisk prediction model
2024
Multilevel Implementation Strategies for Adolescent Human Papillomavirus Vaccine Uptake
Rutten L, Griffin J, St. Sauver J, MacLaughlin K, Austin J, Jenkins G, Herrin J, Jacobson R. Multilevel Implementation Strategies for Adolescent Human Papillomavirus Vaccine Uptake. JAMA Pediatrics 2024, 178: 29-36. PMID: 37983062, PMCID: PMC10957109, DOI: 10.1001/jamapediatrics.2023.4932.Peer-Reviewed Original ResearchConceptsAudit/feedbackReminder/recallHPV vaccine uptakeUsual careHPV vaccinationHPV vaccineVaccine uptakeHuman papillomavirusNational public health goalsHuman papillomavirus vaccine uptakeMultilevel implementation strategyHPV vaccination ratesPrimary care practicesHealth care professionalsEvidence-based interventionsPublic health goalsEvidence-based strategiesAdolescent vaccinesEligible patientsNew cancersPatient receiptVaccination ratesEligible childrenClinical trialsMayo Clinic
2022
Trends and Variation in the Gap Between Current and Anticipated Life Satisfaction in the United States, 2008-2020.
Riley C, Herrin J, Lam V, Parsons AA, Kaplan GA, Liu D, Witters D, Krumholz HM, Roy B. Trends and Variation in the Gap Between Current and Anticipated Life Satisfaction in the United States, 2008-2020. American Journal Of Public Health 2022, 112: 509-517. PMID: 35196041, PMCID: PMC8887183, DOI: 10.2105/ajph.2021.306589.Peer-Reviewed Original Research
2021
National Trends in Racial and Ethnic Disparities in Antihypertensive Medication Use and Blood Pressure Control Among Adults With Hypertension, 2011–2018
Lu Y, Liu Y, Dhingra LS, Massey D, Caraballo C, Mahajan S, Spatz ES, Onuma O, Herrin J, Krumholz HM. National Trends in Racial and Ethnic Disparities in Antihypertensive Medication Use and Blood Pressure Control Among Adults With Hypertension, 2011–2018. Hypertension 2021, 79: 207-217. PMID: 34775785, DOI: 10.1161/hypertensionaha.121.18381.Peer-Reviewed Original ResearchConceptsAntihypertensive medication usePoor hypertension controlOverall treatment rateLow control rateHypertension controlHypertension awarenessMedication useControl rateHispanic individualsEthnic differencesTreatment ratesBlack individualsGuideline-recommended medicationsBlood pressure controlWhite individualsNutrition Examination SurveyLow awareness rateAntihypertensive medicationsHypertensive peopleExamination SurveyIntensive medicationNational HealthAwareness rateEthnic disparitiesPressure controlTrends in Differences in Health Status and Health Care Access and Affordability by Race and Ethnicity in the United States, 1999-2018
Mahajan S, Caraballo C, Lu Y, Valero-Elizondo J, Massey D, Annapureddy AR, Roy B, Riley C, Murugiah K, Onuma O, Nunez-Smith M, Forman HP, Nasir K, Herrin J, Krumholz HM. Trends in Differences in Health Status and Health Care Access and Affordability by Race and Ethnicity in the United States, 1999-2018. JAMA 2021, 326: 637-648. PMID: 34402830, PMCID: PMC8371573, DOI: 10.1001/jama.2021.9907.Peer-Reviewed Original ResearchConceptsHealth care accessFair health statusSelf-reported health statusCare accessHealth statusWhite individualsEthnic differencesLatino/HispanicNational Health Interview Survey dataSerial cross-sectional studySelf-reported functional limitationsBlack individualsHealth Interview Survey dataLow incomeCross-sectional studyCross-sectional survey studyInterview Survey dataSelf-reported raceSelf-report measuresMAIN OUTCOMEUS adultsFunctional limitationsPercentage of peopleSignificant decreaseAdults
2019
What is the effect of a decision aid in potentially vulnerable parents? Insights from the head CT choice randomized trial
Skains RM, Kuppermann N, Homme JL, Kharbanda AB, Tzimenatos L, Louie JP, Cohen DM, Nigrovic LE, Westphal JJ, Shah ND, Inselman J, Ferrara MJ, Herrin J, Montori VM, Hess EP. What is the effect of a decision aid in potentially vulnerable parents? Insights from the head CT choice randomized trial. Health Expectations 2019, 23: 63-74. PMID: 31758633, PMCID: PMC6978876, DOI: 10.1111/hex.12965.Peer-Reviewed Original ResearchConceptsLow health literacyPhysician trustNon-white parentsHealth literacyDecisional conflictImportant traumatic brain injuryTraumatic brain injuryDecision aidLess decisional conflictDisadvantaged parentsGreater increaseUsual careIntermediate riskVulnerable parentsBrain injuryHigher numeracySecondary analysisSubgroup effectsArm assignmentPatient dyadsSocioeconomic statusTrialsRegression modelsParent characteristicsParents
2018
Effect of the Head Computed Tomography Choice Decision Aid in Parents of Children With Minor Head Trauma
Hess EP, Homme JL, Kharbanda AB, Tzimenatos L, Louie JP, Cohen DM, Nigrovic LE, Westphal JJ, Shah ND, Inselman J, Ferrara MJ, Herrin J, Montori VM, Kuppermann N. Effect of the Head Computed Tomography Choice Decision Aid in Parents of Children With Minor Head Trauma. JAMA Network Open 2018, 1: e182430. PMID: 30646167, PMCID: PMC6324506, DOI: 10.1001/jamanetworkopen.2018.2430.Peer-Reviewed Original ResearchConceptsMinor head traumaIntermediate riskHead traumaParents of childrenComputed tomographyDecisional conflictUsual careEmergency departmentImportant traumatic brain injuryCT ratesDecision aid armPatients' mean ageUsual care armUS emergency departmentsHealth care utilizationAvailable diagnostic optionsTraumatic brain injuryDecision aidChildren ages 2Care armSecondary outcomesPrimary outcomeCare utilizationNonwhite raceEligible participantsEvaluating the impact of multilevel evidence-based implementation strategies to enhance provider recommendation on human papillomavirus vaccination rates among an empaneled primary care patient population: a study protocol for a stepped-wedge cluster randomized trial
Finney Rutten LJ, Radecki Breitkopf C, St. Sauver JL, Croghan IT, Jacobson DJ, Wilson PM, Herrin J, Jacobson RM. Evaluating the impact of multilevel evidence-based implementation strategies to enhance provider recommendation on human papillomavirus vaccination rates among an empaneled primary care patient population: a study protocol for a stepped-wedge cluster randomized trial. Implementation Science 2018, 13: 96. PMID: 30001723, PMCID: PMC6043954, DOI: 10.1186/s13012-018-0778-x.Peer-Reviewed Original ResearchConceptsHPV vaccination ratesEvidence-based implementation strategiesStepped-wedge clusterVaccination ratesIntervention 1Human papillomavirusIntervention 2Human papillomavirus (HPV) vaccination ratesPrimary care patient populationPrimary care sitesProvider-level interventionsPractice-level interventionProcess evaluationAdolescent vaccinesBackgroundEach yearHPV vaccineMale patientsPrimary outcomePediatric populationPatient numbersPatient populationProvider recommendationStudy protocolClinical trialsBlock randomizationIdentifying county characteristics associated with resident well-being: A population based study
Roy B, Riley C, Herrin J, Spatz ES, Arora A, Kell KP, Welsh J, Rula EY, Krumholz HM. Identifying county characteristics associated with resident well-being: A population based study. PLOS ONE 2018, 13: e0196720. PMID: 29791476, PMCID: PMC5965855, DOI: 10.1371/journal.pone.0196720.Peer-Reviewed Original ResearchConceptsCounty-level factorsClinical careCross-sectional studyQuality of lifeBetter health outcomesMulti-dimensional assessmentHealth outcomesBeing IndexGallup-Sharecare WellUS residentsCareCounty characteristicsSurvey participantsResident wellUS countiesScoresCounty equivalentsAssessmentFactorsCohort
2017
Predictors of Return Visits Among Insured Emergency Department Mental Health and Substance Abuse Patients, 2005-2013
Lee S, Herrin J, Bobo WV, Johnson R, Sangaralingham LR, Campbell RL. Predictors of Return Visits Among Insured Emergency Department Mental Health and Substance Abuse Patients, 2005-2013. Western Journal Of Emergency Medicine 2017, 18: 884-893. PMID: 28874941, PMCID: PMC5576625, DOI: 10.5811/westjem.2017.6.33850.Peer-Reviewed Original ResearchConceptsED visitsReturn visitsInpatient admissionsOptum Labs Data WarehouseMental healthChronic medical comorbiditiesContinuous insurance enrollmentFirst ED visitIndex ED visitRetrospective cohort studyAdministrative claims dataMedicare Advantage enrolleesPrior EDMedical comorbiditiesCohort studyAcute carePrimary diagnosisStudy inclusionRisk factorsInpatient utilizationClaims dataIncreased ageSubstance abusePatientsStudy period
2016
Trends in Drug Utilization, Glycemic Control, and Rates of Severe Hypoglycemia, 2006–2013
Lipska KJ, Yao X, Herrin J, McCoy RG, Ross JS, Steinman MA, Inzucchi SE, Gill TM, Krumholz HM, Shah ND. Trends in Drug Utilization, Glycemic Control, and Rates of Severe Hypoglycemia, 2006–2013. Diabetes Care 2016, 40: 468-475. PMID: 27659408, PMCID: PMC5360291, DOI: 10.2337/dc16-0985.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBlood GlucoseComorbidityDiabetes Mellitus, Type 2Dipeptidyl-Peptidase IV InhibitorsDrug UtilizationFemaleGlycated HemoglobinHumansHypoglycemiaHypoglycemic AgentsInsulinLogistic ModelsMaleMetforminMiddle AgedRetrospective StudiesSulfonylurea CompoundsThiazolidinedionesYoung AdultConceptsGlycemic controlSevere hypoglycemiaOlder patientsDipeptidyl peptidase-4 inhibitorsGlucose-lowering drugsGlucose-lowering medicationsProportion of patientsOverall glycemic controlPeptidase-4 inhibitorsMedicare Advantage patientsSex-standardized ratesType 2 diabetesOverall rateClass of agentsMore comorbiditiesChronic comorbiditiesYounger patientsAdvantage patientsDrug utilizationClaims dataPatientsHypoglycemiaHemoglobin AT2DMComorbidities
2015
Changing trends in type 2 diabetes mellitus treatment intensification, 2002-2010.
McCoy RG, Zhang Y, Herrin J, Denton BT, Mason JE, Montori VM, Smith SA, Shah ND. Changing trends in type 2 diabetes mellitus treatment intensification, 2002-2010. The American Journal Of Managed Care 2015, 21: e288-96. PMID: 26167776.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdolescentAdultAge FactorsAgedBlood GlucoseComorbidityDiabetes Mellitus, Type 2Drug Therapy, CombinationFemaleGlycated HemoglobinHumansHypoglycemic AgentsIncretinsInsurance Claim ReviewMaleMetforminMiddle AgedResidence CharacteristicsRetrospective StudiesSex FactorsSocioeconomic FactorsSulfonylurea CompoundsUnited StatesYoung AdultConceptsTreatment intensificationCox proportional hazards regression analysisNational administrative data setProportional hazards regression analysisRetrospective secondary data analysisDiabetes treatment intensificationOptimal diabetes careHazards regression analysisDiabetes-related complicationsAdults 18 yearsTreatment-naïve adultsNon-Hispanic whitesComorbidity burdenMetformin monotherapySulfonylurea useMetformin prescriptionThiazolidinedione useGlycemic controlKaplan-MeierMean ageDiabetes careSignificant confoundersSecondary data analysisAdministrative data setsDiabetes therapy
2011
National Performance on Door-In to Door-Out Time Among Patients Transferred for Primary Percutaneous Coronary Intervention
Herrin J, Miller LE, Turkmani DF, Nsa W, Drye EE, Bernheim SM, Ling SM, Rapp MT, Han LF, Bratzler DW, Bradley EH, Nallamothu BK, Ting HH, Krumholz HM. National Performance on Door-In to Door-Out Time Among Patients Transferred for Primary Percutaneous Coronary Intervention. JAMA Internal Medicine 2011, 171: 1879-1886. PMID: 22123793, PMCID: PMC4312661, DOI: 10.1001/archinternmed.2011.481.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionDIDO timeCoronary interventionST-segment elevation acute myocardial infarctionMixed-effects multivariable modelElevation acute myocardial infarctionPrimary percutaneous coronary interventionMedian DIDO timeAcute myocardial infarctionFibrinolytic therapyPatient characteristicsMultivariable analysisEmergency departmentMyocardial infarctionHospital characteristicsMultivariable modelPatientsRural hospitalsHospitalMedicaid ServicesAge categoriesInterventionAfrican AmericansMinutesTreatment timeHow Good Are the Data? Feasible Approach to Validation of Metrics of Quality Derived From an Outpatient Electronic Health Record
Benin AL, Fenick A, Herrin J, Vitkauskas G, Chen J, Brandt C. How Good Are the Data? Feasible Approach to Validation of Metrics of Quality Derived From an Outpatient Electronic Health Record. American Journal Of Medical Quality 2011, 26: 441-451. PMID: 21926280, DOI: 10.1177/1062860611403136.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmbulatory CareChildChild, PreschoolGuideline AdherenceHumansInfantMass ScreeningMedical Records Systems, ComputerizedOutcome and Process Assessment, Health CareOutpatientsPatient SafetyPediatricsPractice Guidelines as TopicQuality Indicators, Health CareQuality of Health CareReproducibility of ResultsImprovements in Door-to-Balloon Time in the United States, 2005 to 2010
Krumholz HM, Herrin J, Miller LE, Drye EE, Ling SM, Han LF, Rapp MT, Bradley EH, Nallamothu BK, Nsa W, Bratzler DW, Curtis JP. Improvements in Door-to-Balloon Time in the United States, 2005 to 2010. Circulation 2011, 124: 1038-1045. PMID: 21859971, PMCID: PMC3598634, DOI: 10.1161/circulationaha.111.044107.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPercutaneous coronary interventionBalloon timeCoronary interventionMedian timeST-segment elevation myocardial infarctionHigher median timeCharacteristics of patientsPercentage of patientsTimeliness of treatmentYears of ageRegistry studyMyocardial infarctionInpatient measuresPatientsHospital groupMedicaid ServicesCalendar yearInterventionMinutesMedianGroupYearsPercentageInfarctionAccess and quality of rural healthcare: Ethiopian Millennium Rural Initiative
Bradley E, Thompson JW, Byam P, Webster TR, Zerihun A, Alpern R, Herrin J, Abebe Y, Curry L. Access and quality of rural healthcare: Ethiopian Millennium Rural Initiative. International Journal For Quality In Health Care 2011, 23: 222-230. PMID: 21467077, DOI: 10.1093/intqhc/mzr013.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedCommunity Health CentersDelivery of Health CareDelivery, ObstetricEthiopiaFemaleHealth Services AccessibilityHealth Services Needs and DemandHIV InfectionsHumansLongitudinal StudiesMaleMiddle AgedPostnatal CarePrenatal CareQuality of Health CareRural PopulationYoung AdultConceptsPrimary healthcare unitsAntenatal care coverageHealth centersAntenatal careCare coverageHealth post levelOutpatient visit ratesHealthcare unitsHealthcare servicesHealth postsRural careUnmet needVisit ratesHIVFocus group participantsRural initiativesOutpatient volumeSystems-based approachGroup participantsRural settingsCareSignificant increaseRural healthcare servicesRural healthcareFocus group data
2010
Variation in Recovery
Lichtman JH, Lorenze NP, D'Onofrio G, Spertus JA, Lindau ST, Morgan TM, Herrin J, Bueno H, Mattera JA, Ridker PM, Krumholz HM. Variation in Recovery. Circulation Cardiovascular Quality And Outcomes 2010, 3: 684-693. PMID: 21081748, PMCID: PMC3064946, DOI: 10.1161/circoutcomes.109.928713.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionYoung AMI patientsAMI patientsYoung womenHeart diseaseSex differencesExcess mortality riskIschemic heart diseaseRisk stratification modelPsychosocial risk factorsYears of ageQuality of careComparison cohortPrognostic factorsPrognostic importanceAMI populationMyocardial infarctionRisk factorsObservational studyMortality riskHigh riskAMI eventsPatientsAge accountWomenThe Effect of How Outcomes Are Framed on Decisions about Whether to Take Antihypertensive Medication: A Randomized Trial
Carling CL, Kristoffersen DT, Oxman AD, Flottorp S, Fretheim A, Schünemann HJ, Akl EA, Herrin J, MacKenzie TD, Montori VM. The Effect of How Outcomes Are Framed on Decisions about Whether to Take Antihypertensive Medication: A Randomized Trial. PLOS ONE 2010, 5: e9469. PMID: 20209127, PMCID: PMC2830888, DOI: 10.1371/journal.pone.0009469.Peer-Reviewed Original ResearchConceptsAntihypertensive medicationsVisual analog scaleCardiovascular diseaseVAS scoresRelative importance scoresCVD risk reductionYear old manLow baseline riskDetailed patient informationRandomized trialsAnalog scaleRisk factorsBaseline riskMedicationsAdult volunteersHypertensionLogistic regressionPatient informationSignificant decreaseTrialsSignificant differencesRisk reductionPresentationParticipantsRisk
2009
The Effect of Alternative Graphical Displays Used to Present the Benefits of Antibiotics for Sore Throat on Decisions about Whether to Seek Treatment: A Randomized Trial
Carling CL, Kristoffersen DT, Flottorp S, Fretheim A, Oxman AD, Schünemann HJ, Akl EA, Herrin J, MacKenzie TD, Montori VM. The Effect of Alternative Graphical Displays Used to Present the Benefits of Antibiotics for Sore Throat on Decisions about Whether to Seek Treatment: A Randomized Trial. PLOS Medicine 2009, 6: e1000140. PMID: 19707579, PMCID: PMC2726763, DOI: 10.1371/journal.pmed.1000140.Peer-Reviewed Original ResearchConceptsSore throatVisual analog scaleBenefits of antibioticsVAS scoresRelative importance scoresDay threeDuration of symptomsTreatment effectsConsequence of treatmentProportion of peopleDetailed patient informationAntibiotic prescriptionsSymptom reliefRandomized trialsAnalog scaleAdult volunteersHealth programsSymptomsLogistic regressionAverage durationPatient informationMost participantsTrialsAntibioticsSignificant differencesThe Effect of Alternative Summary Statistics for Communicating Risk Reduction on Decisions about Taking Statins: A Randomized Trial
Carling CL, Kristoffersen DT, Montori VM, Herrin J, Schünemann HJ, Treweek S, Akl EA, Oxman AD. The Effect of Alternative Summary Statistics for Communicating Risk Reduction on Decisions about Taking Statins: A Randomized Trial. PLOS Medicine 2009, 6: e1000134. PMID: 19707575, PMCID: PMC2724738, DOI: 10.1371/journal.pmed.1000134.Peer-Reviewed Original Research