2024
Risk of Severe Hypoglycemia After Initiation of Noninsulin Glucose-Lowering Therapies in Adults With Type 2 Diabetes at Moderate Cardiovascular Disease Risk
McCoy R, Swarna K, Neumiller J, Polley E, Deng Y, Mickelson M, Herrin J. Risk of Severe Hypoglycemia After Initiation of Noninsulin Glucose-Lowering Therapies in Adults With Type 2 Diabetes at Moderate Cardiovascular Disease Risk. Clinical Diabetes 2024 DOI: 10.2337/cd24-0007.Peer-Reviewed Original ResearchSodium-glucose cotransporter 2Moderate cardiovascular disease riskRisk of severe hypoglycemiaGlucose-lowering therapyCardiovascular disease riskType 2 diabetesSevere hypoglycemiaSodium-glucose cotransporter 2 inhibitorsDPP-4GLP-1 receptor agonistsGlucagon-like peptide 1Risk of hypoglycemiaDPP-4 inhibitorsDipeptidyl peptidase 4Disease riskAvoidance of hypoglycemiaSulfonylurea therapyReceptor agonistsCotransporter 2Sulfonylurea usePatient populationGLP-1Peptidase 4HypoglycemiaEmergency department
2022
1157-P: Mortality among People with Diabetes Experiencing Hypoglycemic and Hyperglycemic Crises
MCCOY R, HERRIN J, SWARNA K, GALINDO R, UMPIERREZ G, GOLDEN S, O'CONNOR P. 1157-P: Mortality among People with Diabetes Experiencing Hypoglycemic and Hyperglycemic Crises. Diabetes 2022, 71 DOI: 10.2337/db22-1157-p.Peer-Reviewed Original ResearchSevere hypoglycemiaPreventable acute complicationEmergency department visitsRelevant patient characteristicsRisk of deathType 2 diabetesHigh-risk individualsType 1 diabetesNovo NordiskRace/ethnicityAdvisory PanelAcute complicationsCause mortalityHyperglycemic crisisPatient characteristicsDepartment visitsKidney diseaseRisk individualsMortality rateSubsequent mortalityHypoglycemiaDiabetesHyperglycemiaMortalityNational Institute
2018
Recurrent hospitalizations for severe hypoglycemia and hyperglycemia among U.S. adults with diabetes
McCoy RG, Herrin J, Lipska KJ, Shah ND. Recurrent hospitalizations for severe hypoglycemia and hyperglycemia among U.S. adults with diabetes. Journal Of Diabetes And Its Complications 2018, 32: 693-701. PMID: 29751961, PMCID: PMC6015781, DOI: 10.1016/j.jdiacomp.2018.04.007.Peer-Reviewed Original ResearchConceptsRecurrent hyperglycemiaRecurrent hypoglycemiaNew glucose-lowering medicationsPost-discharge managementGlucose-lowering medicationsHigh-risk patientsOptumLabs Data WarehouseHypoglycemia hospitalizationIndex dischargeOlder patientsRisk patientsUnrelated causesSevere hypoglycemiaRecurrent hospitalizationsNational cohortEarly recognitionPrincipal diagnosisRisk factorsRetrospective analysisHyperglycemiaHypoglycemiaPatientsReadmissionU.S. adultsHospitalization
2016
Trends in Drug Utilization, Glycemic Control, and Rates of Severe Hypoglycemia, 2006–2013
Lipska KJ, Yao X, Herrin J, McCoy RG, Ross JS, Steinman MA, Inzucchi SE, Gill TM, Krumholz HM, Shah ND. Trends in Drug Utilization, Glycemic Control, and Rates of Severe Hypoglycemia, 2006–2013. Diabetes Care 2016, 40: 468-475. PMID: 27659408, PMCID: PMC5360291, DOI: 10.2337/dc16-0985.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBlood GlucoseComorbidityDiabetes Mellitus, Type 2Dipeptidyl-Peptidase IV InhibitorsDrug UtilizationFemaleGlycated HemoglobinHumansHypoglycemiaHypoglycemic AgentsInsulinLogistic ModelsMaleMetforminMiddle AgedRetrospective StudiesSulfonylurea CompoundsThiazolidinedionesYoung AdultConceptsGlycemic controlSevere hypoglycemiaOlder patientsDipeptidyl peptidase-4 inhibitorsGlucose-lowering drugsGlucose-lowering medicationsProportion of patientsOverall glycemic controlPeptidase-4 inhibitorsMedicare Advantage patientsSex-standardized ratesType 2 diabetesOverall rateClass of agentsMore comorbiditiesChronic comorbiditiesYounger patientsAdvantage patientsDrug utilizationClaims dataPatientsHypoglycemiaHemoglobin AT2DMComorbidities