2024
SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodeling
Xu Y, Zhang H, Chen Y, Pober J, Zhou M, Zhou J, Min W. SRF SUMOylation modulates smooth muscle phenotypic switch and vascular remodeling. Nature Communications 2024, 15: 6919. PMID: 39134547, PMCID: PMC11319592, DOI: 10.1038/s41467-024-51350-5.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsSerum response factorCardiovascular diseaseVSMC synthetic phenotypeVascular remodelingNeointimal formationSENP1 deficiencySerum response factor activitySmooth muscle phenotypic switchingPhenotypic switchingPathogenesis of cardiovascular diseaseSmooth muscle cellsPost-translational SUMOylationTreatment of cardiovascular diseasesInhibitor AZD6244Phospho-ELK1Increased nuclear accumulationLysosomal localizationGene transcriptionNuclear accumulationMuscle cellsCoronary arteryCVD patientsVSMC phenotypic switchTherapeutic potential
2017
Smooth muscle cell differentiation: Mechanisms and models for vascular diseases
Deng Y, Lin C, Zhou H, Min W. Smooth muscle cell differentiation: Mechanisms and models for vascular diseases. Frontiers In Biology 2017, 12: 392-405. DOI: 10.1007/s11515-017-1473-z.Peer-Reviewed Original ResearchVSMC differentiationVascular diseaseVSMC behaviorEnvironmental cuesVSMC phenotypeMolecular mechanismsPhenotypic switchingPhenotype modulationMature cellsNew therapeutic targetsSynthetic stateProgenitor cellsSmooth muscle cellsMuscle cellsCritical roleVascular-related diseasesTherapeutic targetDifferentiationCardiovascular diseaseCardiovascular conditionsCellsContractile stateDiseaseComprehensive understandingPhenotype