A common human skin tumour is caused by activating mutations in β-catenin
Chan E, Gat U, McNiff J, Fuchs E. A common human skin tumour is caused by activating mutations in β-catenin. Nature Genetics 1999, 21: 410-413. PMID: 10192393, DOI: 10.1038/7747.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBeta CateninCytoskeletal ProteinsDeoxyribonucleases, Type II Site-SpecificDNA-Binding ProteinsGene FrequencyHair DiseasesHumansLymphoid Enhancer-Binding Factor 1Molecular Sequence DataMutationPilomatrixomaPolymerase Chain ReactionSequence Analysis, DNASkin NeoplasmsTrans-ActivatorsTranscription FactorsConceptsAdenomatous polyposis coliΒ-cateninLEF/TCFHair matrix cellsΒ-catenin/TCFHair follicle morphogenesisAmino-terminal segmentDownstream transcriptional activationMost colon cancersHuman skin tumorsActivated β-cateninTranscriptional activationCytoplasmic β-cateninTarget genesLEF-1Constitutive activationMatrix cellsWnt pathwayHuman pilomatricomasC-MycSkin tumorsCell tumorigenesisMutationsPolyposis coliBiochemical evidence