Expression and Targeting of the Apoptosis Inhibitor, Survivin, in Human Melanoma
Grossman D, McNiff J, Li F, Altieri D. Expression and Targeting of the Apoptosis Inhibitor, Survivin, in Human Melanoma. Journal Of Investigative Dermatology 1999, 113: 1076-1081. PMID: 10594755, DOI: 10.1046/j.1523-1747.1999.00776.x.Peer-Reviewed Original ResearchConceptsInvasive malignant melanomaMalignant melanomaDominant negative mutantCultured normal human melanocytesCell cycle progressionApoptosis inhibitor Bcl-2G1 DNA contentNormal human melanocytesSurvivin expressionApoptosis inhibitor survivinApoptosis regulationEndogenous survivinNegative mutantTwo-color flow cytometryGenotoxic stimuliMalignant melanoma cell linesSurvivin dominant-negative mutantCycle progressionMetastatic malignant melanomaApoptosis inhibitorMelanoma cell linesHuman melanocytesMIB-1 stainingApoptosis inhibitionCases of nevusImmunohistochemical comparison of cutaneous lymphadenoma, trichoblastoma, and basal cell carcinoma: support for classification of lymphadenoma as a variant of trichoblastoma
McNiff J, Eisen R, Glusac E. Immunohistochemical comparison of cutaneous lymphadenoma, trichoblastoma, and basal cell carcinoma: support for classification of lymphadenoma as a variant of trichoblastoma. Journal Of Cutaneous Pathology 1999, 26: 119-124. PMID: 10235376, DOI: 10.1111/j.1600-0560.1999.tb01815.x.Peer-Reviewed Original ResearchConceptsBasal cell carcinomaVariant of trichoblastomaCutaneous lymphadenomaCell carcinomaLangerhans cellsNodular basal cell carcinomaCK20-positive Merkel cellsS100-positive cellsBcl-2CD30-positive cellsCharacteristic immunohistochemical findingsSimilar staining patternLymphoid infiltratesImmunohistochemical findingsStromal stainingTumor groupEpithelial tumorsImmunohistochemical comparisonUncertain histogenesisMerkel cellsTrichoblastomaS100 proteinCD1aLymphadenomaStaining pattern