1999
Prevention of Graft Versus Host Disease by Inactivation of Host Antigen-Presenting Cells
Shlomchik W, Couzens M, Tang C, McNiff J, Robert M, Liu J, Shlomchik M, Emerson S. Prevention of Graft Versus Host Disease by Inactivation of Host Antigen-Presenting Cells. Science 1999, 285: 412-415. PMID: 10411505, DOI: 10.1126/science.285.5426.412.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsAllogeneic bone marrow transplantationBone marrow transplantationHost diseaseMarrow transplantationT cellsMurine allogeneic bone marrow transplantation modelAllogeneic bone marrow transplantation modelHost-derived antigen-presenting cellsGraft Versus Host DiseaseHost antigen-presenting cellsDonor antigen-presenting cellsVersus Host DiseaseDonor T cellsAllogeneic T cellsBone marrow transplantation modelAlloimmune attackHost antigensTransplantation modelImportant toxicityNeoplastic diseaseDiseaseGraftTransplantationHost tissues
1997
Blockade of CD2-LFA-3 interactions protects human skin allografts in immunodeficient mouse/human chimeras
Sultan P, Schechner J, McNiff J, Hochman P, Hughes C, Lorber M, Askenase P, Pober J. Blockade of CD2-LFA-3 interactions protects human skin allografts in immunodeficient mouse/human chimeras. Nature Biotechnology 1997, 15: 759-762. PMID: 9255790, DOI: 10.1038/nbt0897-759.Peer-Reviewed Original ResearchConceptsSkin graftsLFA-3Human T-cell infiltrationIsotype-matched control antibodyT cell infiltrationSkin graft rejectionHuman skin graftsHuman skin allograftsCD2-LFA-3 interactionHuman LFA-3Microvascular injuryGraft rejectionLeukocyte infiltrationSkin allograftsImmune modulatorsControl antibodyInjury modelImmunodeficient miceImmune reactionsMouse/human chimeraMurine mAbsCD2 interactionPrincipal ligandGraftInjury