2020
Discordant anti‐SARS‐CoV‐2 spike protein and RNA staining in cutaneous perniotic lesions suggests endothelial deposition of cleaved spike protein
Ko CJ, Harigopal M, Gehlhausen JR, Bosenberg M, McNiff JM, Damsky W. Discordant anti‐SARS‐CoV‐2 spike protein and RNA staining in cutaneous perniotic lesions suggests endothelial deposition of cleaved spike protein. Journal Of Cutaneous Pathology 2020, 48: 47-52. PMID: 32895985, DOI: 10.1111/cup.13866.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 spike proteinCOVID toesEccrine epitheliumEndothelial cellsSkin biopsiesSpike proteinReverse transcriptase polymerase chain reaction testingSARS-CoV-2 antibodiesPolymerase chain reaction testingSARS-CoV-2 RNAPotential pathogenetic mechanismsPositive immunohistochemical labelingSARS-CoV-2Endothelial depositionPathogenetic mechanismsImmunohistochemical stainingReaction testingImmunohistochemical labelingEccrine glandsRNA ISHImmunohistochemistrySpike RNAGold standardTissue sectionsBiopsy
1996
Lymphomatoid granulomatosis of the skin and lung. An angiocentric T-cell-rich B-cell lymphoproliferative disorder.
McNiff J, Cooper D, Howe G, Crotty P, Tallini G, Crouch J, Eisen R. Lymphomatoid granulomatosis of the skin and lung. An angiocentric T-cell-rich B-cell lymphoproliferative disorder. JAMA Dermatology 1996, 132: 1464-70. PMID: 8961876, DOI: 10.1001/archderm.132.12.1464.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedB-LymphocytesCell DivisionClone CellsGene Rearrangement, beta-Chain T-Cell Antigen ReceptorGene Rearrangement, gamma-Chain T-Cell Antigen ReceptorGenes, ImmunoglobulinHerpesvirus 4, HumanHumansImmunoglobulin Heavy ChainsImmunophenotypingIn Situ HybridizationLung DiseasesLymphomatoid GranulomatosisMaleMiddle AgedPolymerase Chain ReactionReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaRetrospective StudiesRNA, ViralSkin DiseasesT-LymphocytesConceptsLymphomatoid granulomatosisEpstein-Barr virusEBV RNAB cellsLymphoproliferative disordersPolymerase chain reactionT-cell lymphoproliferative disorderEpstein-Barr virus RNAB-cell lymphoproliferative disordersClonality of lymphocytesT-cell infiltratesAcademic referral centerImmunoglobulin heavy chain gene rearrangementT-cell markersGene rearrangementsT-cell receptor betaChain reactionHeavy chain gene rearrangementClonal immunoglobulin heavy chain gene rearrangementT-cell receptor genesClonal gene rearrangementsChain gene rearrangementAngiocentric infiltratesImmunoglobulin heavy chain geneReferral center