Expression and Targeting of the Apoptosis Inhibitor, Survivin, in Human Melanoma
Grossman D, McNiff J, Li F, Altieri D. Expression and Targeting of the Apoptosis Inhibitor, Survivin, in Human Melanoma. Journal Of Investigative Dermatology 1999, 113: 1076-1081. PMID: 10594755, DOI: 10.1046/j.1523-1747.1999.00776.x.Peer-Reviewed Original ResearchConceptsInvasive malignant melanomaMalignant melanomaDominant negative mutantCultured normal human melanocytesCell cycle progressionApoptosis inhibitor Bcl-2G1 DNA contentNormal human melanocytesSurvivin expressionApoptosis inhibitor survivinApoptosis regulationEndogenous survivinNegative mutantTwo-color flow cytometryGenotoxic stimuliMalignant melanoma cell linesSurvivin dominant-negative mutantCycle progressionMetastatic malignant melanomaApoptosis inhibitorMelanoma cell linesHuman melanocytesMIB-1 stainingApoptosis inhibitionCases of nevus