2013
PD-L1 and PD-L2 Protect The Heart In a T-Cell Receptor Transgenic Model Of Graft-Versus Host Disease
Juchem K, Anderson B, Zhang C, Sharpe A, McNiff J, Demetris A, Shlomchik M, Shlomchik W. PD-L1 and PD-L2 Protect The Heart In a T-Cell Receptor Transgenic Model Of Graft-Versus Host Disease. Blood 2013, 122: 4479. DOI: 10.1182/blood.v122.21.4479.4479.Peer-Reviewed Original ResearchDonor bone marrowPD-L1PD-L1/2T cellsBone marrowLate weight lossWeight lossHost diseasePD-1Graft Versus Host DiseaseInhibitory molecules PD-1Effector memory T cellsT cell receptor transgenic modelAllogeneic stem cell transplantationT-cell-mediated pathogenesisMore chronic phasesPD-L1/2 expressionRadioresistant stromal cellsDays post transplantHost T cellsCD4 T cellsMemory T cellsStem cell transplantationNaive T cellsEarly weight loss
1999
Prevention of Graft Versus Host Disease by Inactivation of Host Antigen-Presenting Cells
Shlomchik W, Couzens M, Tang C, McNiff J, Robert M, Liu J, Shlomchik M, Emerson S. Prevention of Graft Versus Host Disease by Inactivation of Host Antigen-Presenting Cells. Science 1999, 285: 412-415. PMID: 10411505, DOI: 10.1126/science.285.5426.412.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsAllogeneic bone marrow transplantationBone marrow transplantationHost diseaseMarrow transplantationT cellsMurine allogeneic bone marrow transplantation modelAllogeneic bone marrow transplantation modelHost-derived antigen-presenting cellsGraft Versus Host DiseaseHost antigen-presenting cellsDonor antigen-presenting cellsVersus Host DiseaseDonor T cellsAllogeneic T cellsBone marrow transplantation modelAlloimmune attackHost antigensTransplantation modelImportant toxicityNeoplastic diseaseDiseaseGraftTransplantationHost tissues