Bacterial proteins as potential drugs in the treatment of leukemia
Kwan JM, Fialho AM, Kundu M, Thomas J, Hong CS, Gupta T, Chakrabarty AM. Bacterial proteins as potential drugs in the treatment of leukemia. Leukemia Research 2009, 33: 1392-1399. PMID: 19250673, DOI: 10.1016/j.leukres.2009.01.024.Peer-Reviewed Original ResearchConceptsBacterial proteinsSerine/threonine kinaseLeukemia cell linesCaspase recruitment domainCell linesAkt-Ser-473Cell cycle arrestG2/M phaseThreonine kinaseLike domainCARD domainRecruitment domainProtein stabilizationCycle arrestM phaseHL60 cellsProteinActive formPeripheral blood mononuclear cellsBlood mononuclear cellsLeukemia cellsCancer typesAzurinCytotoxic effectsTreatment of leukemia