Featured Publications
High epileptiform discharge burden predicts delayed cerebral ischemia after subarachnoid hemorrhage
Kim JA, Zheng WL, Elmer J, Jing J, Zafar SF, Ghanta M, Moura V, Gilmore EJ, Hirsch LJ, Patel A, Rosenthal E, Westover MB. High epileptiform discharge burden predicts delayed cerebral ischemia after subarachnoid hemorrhage. Clinical Neurophysiology 2021, 141: 139-146. PMID: 33812771, PMCID: PMC8429508, DOI: 10.1016/j.clinph.2021.01.022.Peer-Reviewed Original ResearchConceptsED burdenSubarachnoid hemorrhageEpileptiform dischargesCerebral ischemiaSAH patientsHigh riskOnset of DCIMajor risk periodContinuous EEG recordingsDCI patientsDCI riskRetrospective analysisNovel biomarkersGroup-based trajectory analysisRisk periodPatientsDay 3.5DCIBurdenHemorrhageIschemiaRiskEEG recordingsBurden rateUseful parameter
2022
Epileptiform activity predicts epileptogenesis in cerebral hemorrhage
Kong THJ, Azeem M, Naeem A, Allen S, Kim JA, Struck AF. Epileptiform activity predicts epileptogenesis in cerebral hemorrhage. Annals Of Clinical And Translational Neurology 2022, 9: 1475-1480. PMID: 36030385, PMCID: PMC9463945, DOI: 10.1002/acn3.51637.Peer-Reviewed Original ResearchConceptsEpileptiform activitySubarachnoid hemorrhageRisk factorsRetrospective case-control studyNontraumatic intraparenchymal hemorrhagesDevelopment of epilepsyCase-control studyS scoresClinical seizuresAcute phaseCerebral hemorrhageIntraparenchymal hemorrhageHemorrhageSeizuresEpilepsyScoresEpileptogenesisPatientsActivityIntraparenchymal
2021
Portable, bedside, low-field magnetic resonance imaging for evaluation of intracerebral hemorrhage
Mazurek MH, Cahn BA, Yuen MM, Prabhat AM, Chavva IR, Shah JT, Crawford AL, Welch EB, Rothberg J, Sacolick L, Poole M, Wira C, Matouk CC, Ward A, Timario N, Leasure A, Beekman R, Peng TJ, Witsch J, Antonios JP, Falcone GJ, Gobeske KT, Petersen N, Schindler J, Sansing L, Gilmore EJ, Hwang DY, Kim JA, Malhotra A, Sze G, Rosen MS, Kimberly WT, Sheth KN. Portable, bedside, low-field magnetic resonance imaging for evaluation of intracerebral hemorrhage. Nature Communications 2021, 12: 5119. PMID: 34433813, PMCID: PMC8387402, DOI: 10.1038/s41467-021-25441-6.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingNIH Stroke ScaleIntracerebral hemorrhageHematoma volumeYale-New Haven HospitalStroke care pathwayConventional magnetic resonance imagingBoard-certified neuroradiologistsNew Haven HospitalResource-limited settingsStroke ScaleClinical outcomesLow-field magnetic resonance imagingCare pathwayLow-field magnetic resonanceRadiological examinationConventional neuroimagingAdvanced MRI technologiesResonance imagingCases of disagreementHemorrhageMRI technologyPortable MRINeuroimagingMagnetic resonanceA model of metabolic supply-demand mismatch leading to secondary brain injury
Song JL, Kim JA, Struck AF, Zhang R, Westover MB. A model of metabolic supply-demand mismatch leading to secondary brain injury. Journal Of Neurophysiology 2021, 126: 653-667. PMID: 34232754, PMCID: PMC8815783, DOI: 10.1152/jn.00674.2020.Peer-Reviewed Original ResearchConceptsPrimary brain injurySecondary brain injuryAcute brain injuryBrain injuryExtracellular potassiumAdditional brain injuryAssociation of seizuresIschemic strokeNeurologic insultPreventable complicationsSeizure activityCommon sequalaeTissue hypoxiaMetabolic crisisSeizuresInjuryExcitotoxicityPatientsCommon associationAssociationCurrent practiceExcitotoxityComplicationsHemorrhageIschemia