2000
Safety and Efficacy of Mangafodipir Trisodium (MnDPDP) Injection for Hepatic MRI in Adults: Results of the U.S. Multicenter Phase III Clinical Trials (Safety)
Federle M, Chezmar J, Rubin D, Weinreb J, Freeny P, Semelka R, Brown J, Borrello J, Lee J, Mattrey R, Dachman A, Saini S, Harmon B, Fenstermacher M, Pelsang R, Harms S, Mitchell D, Halford H, Anderson M, Johnson C, Francis I, Bova J, Kenney P, Klippenstein D, Foster G, Turner D, Stillman A, Nelson R, Young S, Patt R, Rifkin M, Seltzer S, Gay S, Robison R, Sherwin P, Ballerini R. Safety and Efficacy of Mangafodipir Trisodium (MnDPDP) Injection for Hepatic MRI in Adults: Results of the U.S. Multicenter Phase III Clinical Trials (Safety). Journal Of Magnetic Resonance Imaging 2000, 12: 186-197. PMID: 10931579, DOI: 10.1002/1522-2586(200007)12:1<186::aid-jmri21>3.0.co;2-2.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal PainAdultAgedAged, 80 and overCardiovascular DiseasesContrast MediaDiagnosis, DifferentialEdetic AcidFemaleHumansImage EnhancementInjections, IntravenousLiver CirrhosisLiver NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedPainPregnancyPyridoxal PhosphateRisk AssessmentSensitivity and SpecificityVomitingConceptsMagnetic resonance imagingMangafodipir trisodium injectionAdverse eventsMulticenter phase III clinical trialContrast-enhanced computed tomography examinationPhase III clinical trialsUnenhanced magnetic resonance imagingInjection of MnDPDPInjection-associated discomfortSerious adverse eventsShort-term safetyHepatic magnetic resonance imagingComputed tomography examinationSignificant short-term riskShort-term riskFocal liver lesionsClinical trialsTomography examinationLaboratory valuesLiver lesionsResonance imagingVital signsPatientsMnDPDPInjection
1994
Effect on fetal mouse development of exposure to MR imaging and gadopentetate dimeglumine
Rofsky N, Pizzarello D, Weinreb J, Ambrosino M, Rosenberg C. Effect on fetal mouse development of exposure to MR imaging and gadopentetate dimeglumine. Journal Of Magnetic Resonance Imaging 1994, 4: 805-807. PMID: 7865940, DOI: 10.1002/jmri.1880040611.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsBody WeightContrast MediaDrug CombinationsEar, ExternalEmbryonic and Fetal DevelopmentExtremitiesEyeFemaleFetal DeathGadoliniumGadolinium DTPAGestational AgeHeadLitter SizeMagnetic Resonance ImagingMeglumineMiceOrganometallic CompoundsPentetic AcidPregnancySodium ChlorideConceptsDays of gestationIntraperitoneal injectionGadopentetate dimeglumineFetal weightEnd pointMR exposureMean fetal weightSaline injection groupMagnetic resonance exposurePregnant miceNormal salineFetal mouse developmentGroup 2Group 1Group 3Control groupGroup 4Group 5MR imagingAdverse effectsDimeglumineSignificant differencesGestationFetusesInjection
1993
Use of the Magnetic Resonance Contrast Agent Gadodiamide in the Central Nervous System Results of a Multicenter Trial
SZE G, BRANT-ZAWADZKI M, McNAMARA M, HAUGHTON V, KUMAR A, MARAVILLA K, AISEN A, DREISBACH J, BRADLEY W, WEINREB J, DRAYER B, TSURUDA J, HESSELINK J, JOHNSON C, ZIMMERMAN R, WEINGAST G. Use of the Magnetic Resonance Contrast Agent Gadodiamide in the Central Nervous System Results of a Multicenter Trial. Investigative Radiology 1993, 28: s49-s55. PMID: 8486504, DOI: 10.1097/00004424-199303001-00006.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingPhase II/III clinical trialsVital signsCentral nervous system resultsSignificant adverse eventsNervous system resultsNonionic contrast agentsVisualization of lesionsPreinjection imagesAdverse eventsNeurologic statusMulticenter trialClinical statusMulticenter studyClinical trialsPatient's vital signsMRI scansGadodiamide injectionPatientsResonance imagingSafety parametersContrast enhancementInjectionTrialsSpine
1991
Multicenter study of gadodiamide injection as a contrast agent in MR imaging of the brain and spine.
Sze G, Brant-Zawadzki M, Haughton V, Maravilla K, McNamara M, Kumar A, Aisen A, Dreisbach J, Bradley W, Weinreb J. Multicenter study of gadodiamide injection as a contrast agent in MR imaging of the brain and spine. Radiology 1991, 181: 693-9. PMID: 1947084, DOI: 10.1148/radiology.181.3.1947084.Peer-Reviewed Original ResearchConceptsCentral nervous systemGadodiamide injectionNervous systemMR imagingSerious adverse eventsContrast material enhancementVisualization of lesionsMagnetic resonance imagingNeurologic statusAdverse eventsMulticenter studyLaboratory valuesPatientsResonance imagingVital signsLesionsUnenhanced imagesSpinePhase IIInjectionMaterial enhancementContrast agentsMR imagesGadolinium chelate complexesImaging