2023
A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes
Wilson F, Yamamoto Y, Martin M, Coronel-Moreno C, Li F, Cheng C, Aklilu A, Ghazi L, Greenberg J, Latham S, Melchinger H, Mansour S, Moledina D, Parikh C, Partridge C, Testani J, Ugwuowo U. A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes. Nature Communications 2023, 14: 2826. PMID: 37198160, PMCID: PMC10192367, DOI: 10.1038/s41467-023-38532-3.Peer-Reviewed Original ResearchConceptsAcute kidney injuryUsual care groupKidney injuryCare groupAcute Kidney Injury OutcomesAlert groupNon-steroidal anti-inflammatory drugsComposite of progressionHours of randomizationMedications of interestAldosterone system inhibitorsClasses of medicationsProton pump inhibitorsRandomized clinical trialsAnti-inflammatory drugsClinical decision support systemNephrotoxic medicationsHospitalized adultsDiscontinuation ratesCertain medicationsPrimary outcomeSubstantial morbiditySystem inhibitorsPump inhibitorsParallel group
2021
Renal Hemodynamics and Renin-Angiotensin-Aldosterone System Profiles in Patients With Heart Failure
Lytvyn Y, Burns KD, Testani JM, Lytvyn A, Ambinathan JPN, Osuntokun O, Godoy LC, Cherney DZI, Parker JD. Renal Hemodynamics and Renin-Angiotensin-Aldosterone System Profiles in Patients With Heart Failure. Journal Of Cardiac Failure 2021, 28: 385-393. PMID: 34487814, DOI: 10.1016/j.cardfail.2021.08.015.Peer-Reviewed Original ResearchMeSH KeywordsAldosteroneBiomarkersDobutamineHeart FailureHemodynamicsHumansNitroprussideReninRenin-Angiotensin SystemConceptsPlasma renin activityRenal blood flowAngiotensin converting enzymeHeart failureArteriolar resistanceGreater renal vascular resistanceEffective renal plasma flowRenal hemodynamic functionRenal vascular resistanceGlomerular filtration rateRenal plasma flowCardiorenal pathophysiologyGomez's equationsLower ERPFAldosterone systemIntravenous dobutamineNeurohormonal activationRenal hemodynamicsRenin activityVascular resistanceRenal profileRenin-AngiotensinHemodynamic functionLower GFRRenal vein
2020
Racial Differences in Diuretic Efficiency, Plasma Renin, and Rehospitalization in Subjects With Acute Heart Failure
Morris AA, Nayak A, Ko YA, D’Souza M, Felker GM, Redfield MM, Tang WHW, Testani JM, Butler J. Racial Differences in Diuretic Efficiency, Plasma Renin, and Rehospitalization in Subjects With Acute Heart Failure. Circulation Heart Failure 2020, 13: e006827. PMID: 32635768, PMCID: PMC7474850, DOI: 10.1161/circheartfailure.119.006827.Peer-Reviewed Original ResearchConceptsPlasma renin activityAcute heart failureLevels of PRADiuretic efficiencyHeart failureBlack patientsNonblack patientsAcute heart failure clinical trialsRacial differencesBaseline plasma renin activityHeart failure clinical trialsHigher diuretic efficiencyMeasures of decongestionRisk of rehospitalizationNonischemic heart failureNet fluid balanceSubset of subjectsGreater fluid lossRace/ethnic groupsCARRESS-HFDOSE-AHFFurosemide equivalentsROSE-AHFAldosterone systemNT-proBNP
2017
Worsening Renal Function and Mortality in Heart Failure
Testani JM, Brisco-Bacik MA. Worsening Renal Function and Mortality in Heart Failure. Circulation Heart Failure 2017, 10: e003835. PMID: 28209768, PMCID: PMC5382499, DOI: 10.1161/circheartfailure.117.003835.Commentaries, Editorials and Letters