2016
The risk of death associated with proteinuria in heart failure is restricted to patients with an elevated blood urea nitrogen to creatinine ratio
Brisco MA, Zile MR, Maaten J, Hanberg JS, Wilson FP, Parikh C, Testani JM. The risk of death associated with proteinuria in heart failure is restricted to patients with an elevated blood urea nitrogen to creatinine ratio. International Journal Of Cardiology 2016, 215: 521-526. PMID: 27153048, PMCID: PMC4986924, DOI: 10.1016/j.ijcard.2016.04.100.Peer-Reviewed Original ResearchConceptsElevated blood urea nitrogenBUN/CrRenal dysfunctionBlood urea nitrogenCreatinine ratioUrea nitrogenLeft Ventricular Dysfunction (SOLVD) trialVentricular Dysfunction trialsGlomerular filtration rateRisk of deathBaseline characteristicsWorsened survivalAdverse eventsHeart failureTop tertileFiltration rateBottom tertileProteinuriaSurvival disadvantagePatientsMortalityTertileDysfunctionSurvivalSurvival models
2010
Potential Effects of Aggressive Decongestion During the Treatment of Decompensated Heart Failure on Renal Function and Survival
Testani JM, Chen J, McCauley BD, Kimmel SE, Shannon RP. Potential Effects of Aggressive Decongestion During the Treatment of Decompensated Heart Failure on Renal Function and Survival. Circulation 2010, 122: 265-272. PMID: 20606118, PMCID: PMC3025294, DOI: 10.1161/circulationaha.109.933275.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood ProteinsBlood VolumeExtracellular FluidFemaleGlomerular Filtration RateHeart FailureHematocritHumansKidneyMaleMiddle AgedPulmonary Wedge PressureSerum AlbuminSodium Chloride Symporter InhibitorsSodium Potassium Chloride Symporter InhibitorsTreatment OutcomeVentricular PressureConceptsDecompensated heart failureRenal functionAggressive decongestionHeart failurePulmonary Artery Catheterization Effectiveness trialPulmonary capillary wedge pressureAggressive fluid removalCapillary wedge pressureIntravascular volume depletionRight atrial pressureCongestive heart failureEvidence of hemoconcentrationAggressive diuresisIntravascular substancesWedge pressureAtrial pressureBaseline characteristicsLoop diureticsTop tertileVolume depletionEffectiveness trialExtravascular fluidFluid removalHemoconcentrationHigh doses