2024
Effects of Sotagliflozin on Health Status in Patients With Worsening Heart Failure Results From SOLOIST-WHF
Bhatt A, Bhatt D, Steg P, Szarek M, Cannon C, Leiter L, McGuire D, Lewis J, Riddle M, Voors A, Metra M, Lund L, Testani J, Wilcox C, Davies M, Pitt B, Kosiborod M. Effects of Sotagliflozin on Health Status in Patients With Worsening Heart Failure Results From SOLOIST-WHF. Journal Of The American College Of Cardiology 2024, 84: 1078-1088. PMID: 39260929, DOI: 10.1016/j.jacc.2024.06.036.Peer-Reviewed Original ResearchConceptsSodium-glucose cotransporter 2Effect of sotagliflozinKCCQ-12 scoreKCCQ-12Heart failureSOLOIST-WHFPrimary endpointSodium-glucose cotransporter 2 inhibitionLeft ventricular ejection fractionWorsening heart failureBaseline to monthVentricular ejection fractionHealth statusWorsening HFKansas City Cardiomyopathy Questionnaire-12Ejection fractionSecondary endpointsCotransporter 2Randomized patientsClinical characteristicsHF hospitalizationPlaceboCardiovascular deathHF episodeSotagliflozin
2016
Different diuretic dose and response in acute decompensated heart failure: Clinical characteristics and prognostic significance
Palazzuoli A, Testani JM, Ruocco G, Pellegrini M, Ronco C, Nuti R. Different diuretic dose and response in acute decompensated heart failure: Clinical characteristics and prognostic significance. International Journal Of Cardiology 2016, 224: 213-219. PMID: 27657476, DOI: 10.1016/j.ijcard.2016.09.005.Peer-Reviewed Original ResearchConceptsLower diuretic efficiencyChronic kidney diseaseDiuretic efficiencyAdverse eventsDose administrationAcute decompensated heart failureDecompensated heart failureAdverse event ratesDiuretic doseWRF occurrenceRenal dysfunctionClinical characteristicsRenal functionHeart failureHD patientsMultivariable analysisClinical statusPrognostic significanceAdverse outcomesContinuous administrationKidney diseaseDE patientsLD patientsBest modalityPatients
2015
Familial dilated cardiomyopathy diagnosis is commonly overlooked at the time of transplant listing
Seidelmann SB, Laur O, Hwa J, Depasquale E, Bellumkonda L, Sugeng L, Pomianowski P, Testani J, Chen M, McKenna W, Jacoby D. Familial dilated cardiomyopathy diagnosis is commonly overlooked at the time of transplant listing. The Journal Of Heart And Lung Transplantation 2015, 35: 474-480. PMID: 26852066, PMCID: PMC5423783, DOI: 10.1016/j.healun.2015.12.002.Peer-Reviewed Original ResearchConceptsEnd-stage heart failureStage heart failureHeart failureUNOS registryEchocardiographic findingsUNOS databaseTeaching hospitalDetailed pedigree analysisVentricular end-diastolic dimensionPanel reactive antibody levelsTertiary care teaching hospitalLarge tertiary teaching hospitalCenter-specific dataAdvanced heart failureEnd-diastolic dimensionOrgan Sharing registryMajority of patientsNon-ischemic DCMTertiary teaching hospitalMitral valve annulusDetailed family historyTransplant listingAdult patientsClinical characteristicsUNOS data
2011
Clinical Characteristics and Outcomes of Patients With Improvement in Renal Function During the Treatment of Decompensated Heart Failure
Testani JM, McCauley BD, Chen J, Coca SG, Cappola TP, Kimmel SE. Clinical Characteristics and Outcomes of Patients With Improvement in Renal Function During the Treatment of Decompensated Heart Failure. Journal Of Cardiac Failure 2011, 17: 993-1000. PMID: 22123361, PMCID: PMC3248245, DOI: 10.1016/j.cardfail.2011.08.009.Peer-Reviewed Original ResearchConceptsDecompensated heart failureRenal functionHeart failureRenal dysfunctionAcute decompensated heart failureVolume of diuresisOutcomes of patientsCongestive heart failureGlomerular filtration rateCardiorenal interactionsIRF patientsClinical characteristicsHemodynamic derangementsConsecutive patientsCardiac dysfunctionDischarge diagnosisPoor prognosisFiltration rateMortality riskEligibility criteriaPatientsGreater incidenceDysfunctionUniversity of PennsylvaniaIRF