2022
Changes in inferior vena cava area represent a more sensitive metric than changes in filling pressures during experimental manipulation of intravascular volume and tone
Ivey‐Miranda J, Wetterling F, Gaul R, Sheridan S, Asher JL, Rao VS, Maulion C, Mahoney D, Mebazaa A, Gray AP, Burkhoff D, Cowie MR, Cox ZL, Butler J, Fudim M, McDonald K, Damman K, Borlaug BA, Testani JM. Changes in inferior vena cava area represent a more sensitive metric than changes in filling pressures during experimental manipulation of intravascular volume and tone. European Journal Of Heart Failure 2022, 24: 455-462. PMID: 34837447, PMCID: PMC9306514, DOI: 10.1002/ejhf.2395.Peer-Reviewed Original ResearchConceptsInferior vena cavaCardiac filling pressuresPulmonary artery pressureIntravascular volumeFilling pressureArtery pressureVolume statusVascular toneCardiac functionCross-sectional areaLeft-sided cardiac filling pressuresIVC cross-sectional areaHeart failure hospitalizationRight heart catheterizationChronic HFFailure hospitalizationHeart catheterizationCardiac dysfunctionVenous conduitsColloid infusionVena cavaVenous systemRapid pacingIVC areaVolume loading
2020
Altered Hemodynamics and End-Organ Damage in Heart Failure
Verbrugge FH, Guazzi M, Testani JM, Borlaug BA. Altered Hemodynamics and End-Organ Damage in Heart Failure. Circulation 2020, 142: 998-1012. PMID: 32897746, PMCID: PMC7482031, DOI: 10.1161/circulationaha.119.045409.Peer-Reviewed Original ResearchConceptsHeart failureHemodynamic derangementsHemodynamic perturbationsElevated cardiac filling pressuresReduced cardiac outputCardiac filling pressuresEnd-organ damagePulmonary vascular diseaseHeart failure phenotypeMultiple organ systemsCapillary stress failureDevelopment of abnormalitiesCardiogenic shockHemodynamic abnormalitiesRenal functionEjection fractionClinical outcomesPulmonary congestionVenous capacityCardiac outputPericardial constraintVascular diseaseChronic diseasesFilling pressureVentilatory control
2018
Hemodynamic factors associated with serum chloride in ambulatory patients with advanced heart failure
Grodin JL, Mullens W, Dupont M, Taylor DO, McKie PM, Starling RC, Testani JM, Tang WHW. Hemodynamic factors associated with serum chloride in ambulatory patients with advanced heart failure. International Journal Of Cardiology 2018, 252: 112-116. PMID: 29249420, DOI: 10.1016/j.ijcard.2017.11.024.Peer-Reviewed Original ResearchConceptsPulmonary capillary wedge pressureAdvanced chronic heart failureFick cardiac indexPulmonary artery systolic pressureRight atrial pressureVentricular assist device placementHeart transplantHeart rateHeart failureSerum chlorideHigher cardiac filling pressuresPoor long-term outcomesSerum Cl levelsCapillary wedge pressureCardiac filling pressuresChronic heart failureAdvanced heart failureInvasive hemodynamic assessmentHeart failure patientsRisk of deathLong-term outcomesLower serum chlorideConventional clinical parametersBackward regression modelAssociation of hemodynamics