2022
Discovery of 42 genome-wide significant loci associated with dyslexia
Doust C, Fontanillas P, Eising E, Gordon SD, Wang Z, Alagöz G, Molz B, Pourcain B, Francks C, Marioni R, Zhao J, Paracchini S, Talcott J, Monaco A, Stein J, Gruen J, Olson R, Willcutt E, DeFries J, Pennington B, Smith S, Wright M, Martin N, Auton A, Bates T, Fisher S, Luciano M. Discovery of 42 genome-wide significant loci associated with dyslexia. Nature Genetics 2022, 54: 1621-1629. PMID: 36266505, PMCID: PMC9649434, DOI: 10.1038/s41588-022-01192-y.Peer-Reviewed Original ResearchConceptsGenome-wide significant lociSignificant lociIndependent genome-wide significant lociWide association studyGenetic covarianceAssociation studiesGenetic markersLociGenetic etiologyEuropean ancestryTraitsPolygenic scoresCrucial life skillGenesHeritabilityIndependent cohortAncestryFamily studiesDiscoveryOrthographic Depth May Influence the Degree of Severity of Maze Learning Performance in Children at Risk for Reading Disorder
Gabel L, Battison A, Truong D, Lindström E, Voss K, Yu Y, Roongruengratanakul S, Shyntassov K, Riebesell S, Toumanios N, Nielsen-Pheiffer C, Paniagua S, Gruen J. Orthographic Depth May Influence the Degree of Severity of Maze Learning Performance in Children at Risk for Reading Disorder. Developmental Neuroscience 2022, 44: 651-670. PMID: 36223729, PMCID: PMC9928771, DOI: 10.1159/000527480.Peer-Reviewed Original ResearchConceptsLow reading skillsOrthographic depthReading skillsNative EnglishSame neural networkLack of textCognitive predictorsReading networkCognitive processesImpaired performanceGenetic riskLanguage orthographyDegree of impairmentDiverse sampleActivation patternsNeural networkNative GermansTaskOral reportingMazeOrthographyRecent researchImpairmentChildrenEnglish
2013
Associations of Prenatal Nicotine Exposure and the Dopamine Related Genes ANKK1 and DRD2 to Verbal Language
Eicher JD, Powers NR, Cho K, Miller LL, Mueller KL, Ring SM, Tomblin JB, Gruen JR. Associations of Prenatal Nicotine Exposure and the Dopamine Related Genes ANKK1 and DRD2 to Verbal Language. PLOS ONE 2013, 8: e63762. PMID: 23691092, PMCID: PMC3655151, DOI: 10.1371/journal.pone.0063762.Peer-Reviewed Original ResearchConceptsPrenatal nicotine exposureANKK1/DRD2Nicotine exposureNicotine dependenceDose-response fashionAvon Longitudinal StudyCase-control cohortAssociation of markersPrenatal environmental factorsPrenatal nicotineLanguage impairmentLanguage tasksNeurobehavioral disordersEtiological determinantsNeural circuitsUtero developmentLongitudinal studyDRD2Communication disordersRiskRelated pathwaysAssociationExposureDisordersANKK1