2016
Multipoint genome-wide linkage scan for nonword repetition in a multigenerational family further supports chromosome 13q as a locus for verbal trait disorders
Truong DT, Shriberg LD, Smith SD, Chapman KL, Scheer-Cohen AR, DeMille MM, Adams AK, Nato AQ, Wijsman EM, Eicher JD, Gruen JR. Multipoint genome-wide linkage scan for nonword repetition in a multigenerational family further supports chromosome 13q as a locus for verbal trait disorders. Human Genetics 2016, 135: 1329-1341. PMID: 27535846, PMCID: PMC5065602, DOI: 10.1007/s00439-016-1717-z.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChildChild, PreschoolChromosome MappingChromosomes, Human, Pair 13Drosophila ProteinsDyslexiaFemaleGenetic LinkageGenetic Predisposition to DiseaseGenotypeHumansLanguage DisordersLod ScoreMaleMembrane ProteinsMiddle AgedNuclear ProteinsPedigreeQuantitative Trait LociReadingSpeech DisordersWritingConceptsNonword repetitionSpecific language impairmentCognitive processesLanguage impairmentAuditory processingVerbal developmentMotor planningPerson's abilityRobust endophenotypesMultigenerational familiesLanguage traitsRepetitionDisordersGenome-wide linkage scanSpellingVariance component linkage analysisCausal genetic factorsMultipoint variance component linkage analysisMemoryEndophenotypesSpeechChromosome 13qFuture studiesPresent studyDeficits
2012
DCDC2 genetic variants and susceptibility to developmental dyslexia
Marino C, Meng H, Mascheretti S, Rusconi M, Cope N, Giorda R, Molteni M, Gruen JR. DCDC2 genetic variants and susceptibility to developmental dyslexia. Psychiatric Genetics 2012, 22: 25-30. PMID: 21881542, PMCID: PMC3232293, DOI: 10.1097/ypg.0b013e32834acdb2.Peer-Reviewed Original ResearchConceptsDevelopmental dyslexiaQuantitative transmission disequilibrium test analysesNonword readingNonword spellingOrthographic choiceMarker-trait associationsQuantitative trait lociDyslexiaMemory impairmentRelated readingsTrait lociQuantitative traitsQuantitative transmission disequilibrium testTransmission disequilibrium test analysisPhenotypic complexityAssociation evidenceGenetic linkageMemoryAssociation analysisDCDC2WordsGenetic variantsTransmission disequilibrium testReadingPerformance tests